Colon Cancer

Abstract

Colon cancer is a neoplastic disease of the large intestine, which can be derived from both inherited or somatic genetic alterations that develop over the course of a lifetime. Prevention together with early detection and treatment are the keys to a successful outcome for this very common disease.

Keywords: oncogene; tumour suppressor gene; mucosal lining; large intestine; p53 gene; familial adenomatous polyposis; hereditary nonpolyposis colon cancer

Figure 1.

Anatomy of the large intestine. The colon is divided into four sections: caecum and ascending, transverse, descending, and sigmoid. The rectum forms the most distal portion of the large intestine.

Figure 2.

Multistep model of colon cancer progression includes alterations in both oncogenes and tumour suppressor genes.

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Yeatman, Timothy J(Jan 2003) Colon Cancer. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0001891]