Mohsen Meydani, Tufts University, Boston, Massachusetts, USA
Takuro Koga, Tufts University, Boston, Massachusetts, USA
Samina Ali, Tufts University, Boston, Massachusetts, USA
Published online: January 2003
DOI: 10.1038/npg.els.0002109
Vitamin E is essential for the integrity of cellular membranes and deficiency of it results in membrane lipid peroxidation, dysfunction and cell death. Nutritional vitamin E deficiency is rare in humans, but rare genetic defects lead to tissue deficiency despite normal intestinal absorption.
Keywords: vitamin E; deficiency; neuropathy; fat malabsorption; tocopherol transport protein
References
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Further Reading
Arita M, Sato Y, Miyato A et al. (1995) Human alpha‐tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Journal of Biochemistry 306: 437–443.
Fernandez‐Zamorano A, Arnalich F, Codoceo R et al. (1988) Hemolytic anaemia and susceptibility to hydrogen‐peroxide hemolysis in children with vitamin E‐deficiency and chronic liver disease. Journal of Medicine 18: 317–334.
Kaempf DE and Linderkamp O (1998) Do healthy premature infants fed breast milk need vitamin E supplementation: alpha‐ and gamma‐tocopherol levels in blood components and buccal mucosal cells. Pediatrics Research 44: 54–59.
Meydani SN and Hayek M (1992) Vitamin E and immune response. Chandra RK Proceedings of International Conference on Nutrition and Immunity, pp. 105–128. St John's, Newfoundland: ARTS Biomedical Publishers and Distributors
Peters SA and Kelly FJ (1996) Vitamin E supplementation in cystic fibrosis. Journal of Pediatrics Gastroenterology and Nutrition 22: 341–345.
Muller DP (1992) Vitamin E therapy in retinopathy of prematurity. Eye 6: 221–225.
Traber MG, Sokol RJ, Ringel SP, Neville HE, Thellman CA and Kayden HJ (1987) Lack of tocopherol in peripheral nerves of vitamin E‐deficient patients with peripheral neuropathy. New England Journal of Medicine 317: 262–265.
Sokol RJ, Butler‐Simon N, Conner C et al. (1993) Multicenter trial of d‐alpha‐tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology 104: 1727–1735.
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