Ischaemic Heart Disease

David Lewis, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Qing Wang, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Eric Topol, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

Published online: April 2001

DOI: 10.1038/npg.els.0002113

The clinical spectrum of ischaemic heart disease encompasses a variety of acute and chronic conditions including silent ischaemia, chronic stable angina, myocardial infarction, ischaemic cardiomyopathy and sudden cardiac death. Its pathogenesis and treatment is the subject of much ongoing research and debate.

Keywords: atherosclerosis; myocardial infarction; congestive heart failure; coronary artery disease; thrombolysis

Figure 1. Changes in mortality rates for coronary heart disease (CHD), stroke, and noncardiovascular disease (CVD) in the USA since 1950, age-adjusted to the 2000 standard. aComparability ratio applied to rates for the years 1968–1978. bTotal mortality minus CVD (excluding congenital). From National Institute of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) Morbidity and Mortality (1998) Chartbook on Cardiovascular, Lung, and Blood Diseases.
Figure 2. Drawing of a nonobstructive atheromatous plaque in a coronary artery.
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 References
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 Further Reading
    Frye RL et al. for the BARI Investigators (1996) Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. New England Journal of Medicine 335: 217–225.
    Gibbons RJ, Chatterjee K, Daley J et al. (1999) ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina. Journal of the American College of Cardiology 33(7): 2092–2197.
    Little WC, Constantinescu M, Applegate RJ et al. (1988) Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 78: 1157–1166.
    NCEP Expert Panel (1993) Summary of the second report of the national cholesterol education program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel II). Journal of the American Medical Association 269(23): 3015–3023.
    Ross R (1999) Atherosclerosis – an inflammatory disease. New England Journal of Medicine 340: 115–126.
    Ryan TJ, Anderson JL, Antman EM et al. (1996) ACC/AHA guidelines for the management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on Management of Acute Myocardial Infarction). Journal of the American College of Cardiology 28: 1328–1428.
    Stary HC, Chandler AB, Glagov S et al. (1994) A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. Circulation 9: 2462–2478.
    book Topol EJ and Van de Werf FJ (1998) "Acute myocardial infarction: early diagnosis and management". In: Topol EJ (ed.) Comprehensive Cardiovascular Medicine, pp. 425–466. Philadelphia, PA: Lippincott Raven Publishers.

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Inflammation | Health Care
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Article Title: Ischaemic Heart Disease
 
How to Cite close
Lewis, David, Wang, Qing, and Topol, Eric(Apr 2001) Ischaemic Heart Disease. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002113]