Diffuse Parenchymal Lung Disease

Abstract

Diffuse parenchymal lung diseases predominately affect the acinar regions of the lung. Some types of the disease are relatively common, while others are extremely rare, but taken together they affect roughly 1 in 3–4000 of the UK population and in many cases there is irreversible scarring.

Keywords: diffuse lung disease; diagnostic algorithm; bronchoalveolar lavage; high‐resolution computed tomography; radionuclide imaging; therapy

Figure 1.

Structures within the lung affected by diffuse parenchymal lung diseases. (a) A terminal respiratory unit – the acinus. (b) The alveolar–endothelial interface and ‘the interstitium’.

Figure 2.

Protocol for the investigation of diffuse parenchymal lung disease.

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References

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Further Reading

Black CM and du Bois RM (1995) Organ involvement: pulmonary. In: Clements PJ and Furst DE (eds) Systemic Sclerosis, pp. 299–332. Baltimore: Williams & Wilkins.

du Bois RM (1994) Diffuse lung disease: an approach to management. British Medical Journal 309: 175–179.

du Bois RM (guest ed.) (1998) Pulmonary vascular disease. Seminars in Respiratory and Critical Care Medicine 19: 1–96.

du Bois RM and Turner‐Warwick M (1996) Diffuse parenchymal lung disease. In: Brewis RA, Corrin B, Geddes DM and Gibson GJ (eds) Respiratory Medicine, pp. 1365–1375. London: WB Saunders.

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Newman‐Taylor AJ (1996) Extrinsic allergic alveolitis. In: Brewis RA, Corrin B, Geddes DM and Gibson GJ (eds) Respiratory Medicine, pp. 1394–1402. London: WB Saunders.

Tazi A and Hance AJ (1995) Pulmonary histiocytosis X. In: Walters EH and du Bois RM (eds) Immunology and Management of Interstitial Lung Diseases, pp. 305–318. London: Chapman and Hall.

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How to Cite close
Ranasinha, CD, and Bois, RM du(Apr 2001) Diffuse Parenchymal Lung Disease. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002132]