Cytokines as Mediators of Disease


Virtually all insults to the body involve cytokine responses, and nearly every type of disease has a cytokine component. An understanding of the cytokine component of diseases is leading to new approaches to treatment.

Keywords: cytokine; inflammation; infection; cancer; autoimmunity; allergy


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Further Reading

Anderson KC and Lust JA (1999) Role of cytokines in multiple myeloma. Seminars in Hematology 36: 14–20.

Balkwill FR (ed.) (2000) Frontiers in Molecular Biology: The Cytokine Network. Oxford: Oxford University Press.

Bellanti JA (1998) Cytokines and allergic disease: clinical aspects. Allergy and Asthma Proceedings 19: 337–341.

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Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F and Kollias G (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU‐rich elements: implications for joint and gut‐associated immunopathologies. Immunity 10: 387–398.

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Wilson AG, di Giovine FS and Duff GW (1995) Genetics of tumour necrosis factor‐α in autoimmune, infectious and neoplastic diseases. Journal of Inflammation 45: 1–12.

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How to Cite close
Balkwill, Frances R(Jan 2003) Cytokines as Mediators of Disease. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0002145]