Polymorphism of TNF Genes and Disease Susceptibility

Abstract

Deoxyribonucleic acid (DNA) sequence variation (polymorphism) occurs commonly between individuals. Polymorphism of the TNF (encoding tumour necrosis factor) gene region has been implicated in defining susceptibility to many infectious, inflammatory and autoimmune diseases.

Keywords: polymorphism; heredity; complex disease; tumour necrosis factor; lymphotoxin alpha

Figure 1.

Genomic location of the TNF locus (LTA, TNF and LTB) on chromosome 6p21 within the MHC. The multivariant TNF microsatellites (TNFa–e) are highlighted in green, while a collection of TNF and LTASNPs discussed in this paper are highlighted in red.

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References

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Further Reading

Dean M (2003) Approaches to identify genes for complex human diseases: lessons from Mendelian disorders. Human Mutation 22: 261–274.

Field M (2001) Tumour necrosis factor polymorphisms in rheumatic diseases. Quarterly Journal of Medicine 94: 237–246.

Glazier AM, Nadeau JH and Aitman TJ (2002) Finding genes that underlie complex traits. Science 298: 2345–2349.

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Holmes CL, Russell JA and Walley KR (2003) Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy. Chest 124: 1103–1115.

Knight J (2001) Polymorphisms in tumor necrosis factor and other cytokines as risks for infectious diseases and the septic syndrome. Current Infectious Disease Reports 3: 427–439.

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How to Cite close
Knight, Julian Charles, and Keating, Brendan James(Jan 2006) Polymorphism of TNF Genes and Disease Susceptibility. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002186]