Polymorphism of TNF Genes and Disease Susceptibility


Deoxyribonucleic acid (DNA) sequence variation (polymorphism) occurs commonly between individuals. Polymorphism of the TNF (encoding tumour necrosis factor) gene region has been implicated in defining susceptibility to many infectious, inflammatory and autoimmune diseases.

Keywords: polymorphism; heredity; complex disease; tumour necrosis factor; lymphotoxin alpha

Figure 1.

Genomic location of the TNF locus (LTA, TNF and LTB) on chromosome 6p21 within the MHC. The multivariant TNF microsatellites (TNFa–e) are highlighted in green, while a collection of TNF and LTA SNPs discussed in this paper are highlighted in red.



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Further Reading

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Knight J (2001) Polymorphisms in tumor necrosis factor and other cytokines as risks for infectious diseases and the septic syndrome. Current Infectious Disease Reports 3: 427–439.

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Knight, Julian Charles, and Keating, Brendan James(Jan 2006) Polymorphism of TNF Genes and Disease Susceptibility. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002186]