Movement Disorders


Movement disorders comprise a wide group of neurologic conditions seen by the practicing physician. Abnormal movements are characterized by their phenomenology with much differentiation made by their speed (hypokinetic=‘too slow’ and hyperkinetic=‘too fast’). Such findings may be described as parkinsonism, tremor, dystonia, chorea, athetosis, ballism, myoclonus, tics and/or ataxia. Familiar movement disorder diagnoses include Parkinson disease, Huntington disease and Tourette syndrome. Most movement disorders arise from abnormalities within the basal ganglia and its connections. Symptomatic treatment is available for most conditions, but complete resolution or cure remains elusive.

Keywords: Parkinson disease; tremor; dystonia; chorea; tics; ataxia


Anderson KE (2005) Huntington's disease and related disorders. Psychiatric Clinics of North America 28(1): 275–290.

Bhidayasiri R (2005) Differential diagnosis of common tremor syndromes. Postgraduate Medical Journal 81(962): 756–762.

Cardoso F, Seppi K, Mair KJ, Wenning GK and Poewe W (2006) Seminar on choreas. Lancet Neurology 5(7): 589–602.

Caviness JN and Brown P (2004) Myoclonus: current concepts and recent advances. Lancet Neurology 3(10): 598–607.

Chaudhuri KR, Healy DG and Schapira AH (2006) National Institute for Clinical Excellence. Non‐motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurology 5(3): 235–245.

Deuschl G and Schade‐Brittinger C (2006) German Parkinson Study Group, Neurostimulation Section. A randomized trial of deep‐brain stimulation for Parkinson's disease. New England Journal of Medicine 355(9): 896–908.

Faught E (2003) Clinical presentations and phenomenology of myoclonus. Epilepsia 44(suppl. 11): 7–12.

Fogel BL and Perlman S (2007) Clinical features and molecular genetics of autosomal recessive cerebellar ataxias. Lancet Neurology 6(3): 245–257.

Gibb WR and Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry 51: 745–752.

Gilman S, Wenning GK and Low PA (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(9): 670–676.

Halpern C, Hurtig H and Jaggi J (2007) Deep brain stimulation in neurologic disorders. Parkinsonism & Related Disorders 13(1): 1–16.

Hardy J, Cai H, Cookson MR, Gwinn‐Hardy K and Singleton A (2006) Genetics of Parkinson's disease and parkinsonism. Annals of Neurology 60(4): 389–398.

Jankovic J (2006) Treatment of dystonia. Lancet Neurology 5(10): 864–872.

Jankovic J (2001) Tourette's syndrome. New England Journal of Medicine 345(16): 1184–1192.

Leckman JF (2003) Phenomenology of tics and natural history of tic disorders. Brain Development 25(suppl. 1): S24–S28.

Litvan I (2004) Update on progressive supranuclear palsy. Current Neurology and Neuroscience Reports 4(4): 296–302.

Louis ED (2005) Essential tremor. Lancet Neurology 4(2): 100–110.

Manto MU (2005) The wide spectrum of spinocerebellar ataxias (SCAs). Cerebellum 4(1): 2–6.

McKeith IG, Dickson DW, Lowe J et al. and Consortium on DLB (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65(12): 1863–1872.

Miyasaki JM, Martin W, Suchowersky O, Weiner WJ and Lang AE (2002) Practice parameter: initiation of treatment for Parkinson's disease: an evidence‐based review: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 58(1): 11–17.

Morgan JC and Sethi KD (2005) Drug‐induced tremors. Lancet Neurology 4(12): 866–876.

Olanow CW, Hauser RA and Jankovic J (2008) A randomized, double‐blind, placebo‐controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson's disease (the ADAGIO study): rationale, design, and baseline characteristics. Movement Disorders 23(15): 2194–2201.

Patten J (1996) The Extrapyramidal System and the Basal Ganglia. Neurological Differential Diagnosis, pp. 178–212. New York: Springer.

Parkinson J (1817) An Essay on the Shaking Palsy. London: Sherwood, Nelly, and Jones.

Przedborski S (2006) Etiology and pathogenesis of Parkinson's disease. In: Jankovic J and Tolosa E (eds) Parkinson's Disease and Movement Disorders, pp. 77–92. Lippincott Williams and Wilkins.

Rampello L, Alvano A and Battaglia G (2006) Tic disorders: from pathophysiology to treatment. Journal of Neurology 253(1): 1–15.

Schrag A and Lang AE (2005) Psychogenic movement disorders. Current Opinion in Neurology 18(4): 399–404.

Shibasaki H and Hallett M (2005) Electrophysiological studies of myoclonus. Muscle & Nerve 31(2): 157–174.

Sydenham T (1686) Schedula monitoria de novae febris ingressu. London: Typis R. N. Impensis Gualt. Kettilby.

Tarsy D and Simon DK (2006) Dystonia. New England Journal of Medicine 355(8): 818–829.

Tolosa E, Wenning G and Poewe W (2006) The diagnosis of Parkinson's disease. Lancet Neurology 5(1): 75–86.

Wadia PM and Lang AE (2007) The many faces of corticobasal degeneration. Parkinsonism & Related Disorders 13(suppl. 3): S336–S340.

Wichmann T and DeLong MR (1996) Functional and pathophysiological models of the basal banglia. Current Opinion in Neurobiology 6(6): 751–758.

Further Reading

Hallett M (1998) The neurophysiology of dystonia. Archives of Neurology 55(5): 601–603.

Houghton DJ and Kleiner‐Fisman G (2007) Subthalamic nucleus deep brain stimulation and nonmotor symptoms in Parkinson's disease. In: Baltuch GH and Stern MB (eds) Deep Brain Stimulation for Parkinsons's Disease, pp. 219–246. Philadelphia: Informa HealthCare.

Hughes AJ, Daniel SE, Ben‐Shlomo Y and Lees AJ (2002) The accuracy of diagnosis of Parkinsonian syndromes in a specialist movement disorder service. Brain 125(4): 861–870.

Jankovic J (2008) Parkinson's disease: clinical features and diagnosis. Journal of Neurology, Neurosurgery, and Psychiatry 79(4): 368–376.

Lees AJ (2007) Unresolved issues relating to the shaking palsy on the celebration of James Parkinson's 250th birthday. Movement Disorders 22(suppl. 17): S327–S334.

Schols L, Bauer P, Schmidt T, Schulte T and Riess O (2004) Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurology 3(5): 291–304.

Singer HS (2005) Tourette's syndrome: from behaviour to biology. Lancet Neurology 4(3): 149–159.

Suchowersky O, Gronseth G, Perlmutter J et al. (2006) Quality Standards Subcommittee of the American Academy of Neurology. Practice Parameter: neuroprotective strategies and alternative therapies for Parkinson disease (an evidence‐based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 66(7): 976–982.

Weiner WJ (2008) There is no Parkinson disease. Archives of Neurology 65(6): 705–708.

Weintraub D and Stern MB (2005) Psychiatric complications in Parkinson disease. American Journal of Geriatric Psychiatry 13(10): 844–851.

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Houghton, David J, and Hurtig, Howard I(Sep 2009) Movement Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0002190]