Benign Intracranial Hypertension

Abstract

Benign (idiopathic) intracranial hypertension, or pseudotumour cerebri, is characterized by a sustained increase in intracranial pressure in the absence of tumour, infection or obstruction. There are persistent, usually low grade, headaches and frequently there is impairment of visual acuity.

Keywords: pseudotumor cerebri; idiopathic intracranial hypertension; headache; papilloedema; visual impairment

References

Baker RS and Buncie JR (1985) Vertical ocular motility disturbance in pseudotumor cerebri. Journal of Clinical Neuro‐ophthalmology 5: 41–44.

Capobianco DJ, Brazis PW and Cheshire WP (1987) Idiopathic intracranial hypertension and seventh nerve palsy. Headache 37: 286–288.

Chutorian AM, Gold AP and Braun CW (1977) Benign intracranial hypertension and Bell's palsy. New England Journal of Medicine 21: 1214–1215.

Corbett JJ and Mehta MP (1983) Cerebrospinal fluid pressure in normal obese subjects and patients with pseudotumor cerebri. Neurology 33: 1386–1388.

Corbett JJ, Savino PJ, Thompson HS et al. (1982) Visual loss in pseudotumor cerebri. Follow‐up of 57 patients from five to 41 years and a profile of 14 patients with permanent severe visual loss. Archives of Neurology 39: 461–474.

Davidoff LM (1956) Pseudotumor cerebri: benign intracranial hypertension. Neurology 6: 605.

Duncan FJ, Corbett JJ and Wall M (1988) The incidence of pseudotumor cerebri. Population studies in Iowa and Louisiana. Archives of Neurology 45: 875–877.

Eggenberger ER, Miller NR and Vitale S (1996) Lumboperitoneal shunt for the treatment of pseudotumor cerebri. Neurology 45(6): 1524–1530.

Giuseffi V, Wall M and Siegel PZ (1991) Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case–control study. Neurology 41: 239–244.

Gjerris F, Sorensen S, Vorstrup S and Paulson OB (1985) Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow in patients with idiopathic intracranial hypertension (pseudotumor cerebri). Annals of Neurology 17: 158–162.

Grant DN (1971) Benign intracranial hypertension: a review of 79 cases in infancy and childhood. Archives of Disease in Childhood 46: 651–655.

Greer M (1990) Pseudotumor cerebri. In: Youmans JR (ed.) Neurological Surgery, 3rd edn, pp. 3414–3530. Philadelphia: WB Saunders.

Hagbers B and Sillinää M (1970) Benign intracranial hypertension (pseudotumor cerebri). Acta Paediatrica Scandinavica 59: 328–329.

Halpern JI and Gordon WH (1981) Trochlear nerve palsy as a false localizing sign. Annals of Ophthalmology 13: 53–56.

Jacobson DM, Berg R, Wall M et al. (1999) Serum vitamin A concentration is elevated in idiopathic intracranial hypertension. Neurology 53(5): 1114–1118.

Jalan R, Damink SW, Deutz ME, Les A and Hayes PC (1999) Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. Lancet 354: 1164–1168.

Johnston I and Paterson A (1974) Benign intracranial hypertension. II. CSF pressure and circulation. Brain 97: 301–312.

Johnston I, Paterson A and Besser M (1981) The treatment of benign intracranial hypertension: a review of 134 cases. Surgical Neurology 16: 218–224.

Kelman SE, Heaps R, Wolf A and Elman MJ (1992) Optic nerve decompression surgery improves visual function in patients with pseudotumor cerebri. Neurosurgery 30: 391–395.

Landan I, Policheria H and McLaurin J (1987) Complete external ophthalmoplegia in a case of pseudotumor cerebri. Headache 27: 573–574.

Lascari AD and Bell WE (1970) Pseudotumor cerebri due to hypervitaminosis. Clinical Pediatrics 9: 627–628.

Lee AG (1995) Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne. Cutis 55: 165–168.

Levine SH and Puchalski C (1990) Pseudotumor cerebri associated with lithium therapy in two patients. Journal of Clinical Psychiatry 51: 251–253.

Lorrot M, Bader‐Meunier B, Sebire G and Dommergues JP (1999) Benign intracranial hypertension: an unrecognized complication of corticosteroid therapy. Archives of Pediatrics 6(1): 40–42.

Marcelis J and Silberstein SD (1991) Idiopathic intracranial hypertension without papilledema. Archives of Neurology 46: 392–399.

Mauriello JA, Shaderowsky P, Gizzi M and Frohman L (1995) Management of visual loss after optic nerve sheath decompression in patients with pseudotumor cerebri. Ophthalmology 102: 441–445.

McCammon A, Kaufman HH and Sears ES (1981) Transient oculomotor paralysis in pseudotumor cerebri. Neurology 31: 182–184.

Milhorat TH (1972) Hydrocephalus and Cerebrospinal Fluid. Baltimore: Williams and Wilkins.

Murphy TO (1991) Otologic manifestations of pseudotumor cerebri. Journal of Otolaryngology 20: 258–261.

Reid AC and Thomas JA (1981) Absence of significant endocrine deficiencies in benign intracranial hypertension. Journal of Neurology, Neurosurgery and Psychiatry 44: 731–734.

Reid AC, Teasdale GM, Matheson MS and Teasdale ME (1982) Serial ventricular volume measurements; further insights into the etiology and pathogenesis of benign intracranial hypertension. Journal of Neurology, Neurosurgery and Psychiatry 44: 636–640.

Robertson DM, Hines JD and Rucker CW (1970) Acquired sixth nerve paresis in children. Archives of Ophthalmology 83(5): 574–579.

Rosenberg ML, Corbett JJ, Smith C et al. (1993) Cerebrospinal fluid diversion procedures in pseudotumor cerebri. Neurology 43: 1071–1072.

Rush JA (1980) Pseudotumor cerebri: clinical profile and visual outcome in 63 patients. Mayo Clinic Proceedings 55: 541–546.

Sandborn GE, Selhorst JB, Colabrese VP et al. (1978) Pseudotumor cerebri and insecticide intoxication. Neurology 29: 1222–1227.

Selky AK, Dobyns WB and Yee RD (1994) Idiopathic intracranial hypertension and facial diplegia. Neurology 44: 357.

Sklar FH, Beyer CWA, Remanathan M, Cooper PR and Clark WK (1979) Cerebrospinal fluid dynamics in patients with pseudotumor cerebri. Neurosurgery 5: 208–216.

Snyder DA and Frankel M (1979) An unusual presentation of pseudotumor cerebri. Annals of Ophthalmology 11: 1823–1827.

Sorensen PS, Gjerris F and Svenstrup B (1986) Endocrine studies in patients with pseudotumor cerebri. Estrogen levels in blood and cerebrospinal fluid. Archives of Neurology 43: 902–906.

Sorensen PS, Krogsan B and Gjerris F (1988) Clinical course and prognosis of pseudotumor cerebri. A prospective study of 24 patients. Acta Neurologica Scandinavica 77: 164–172.

Sorensen PS, Thomsen C, Gjerris F et al. (1989) Increased brain water content in pseudotumor cerebri measured by magnetic resonance imaging of brain water self diffusion. Neurological Research 11: 160–164.

Swerdlow RH and Hanna GR (1996) Behçet's disease: presentation with sagittal sinus thrombosis diagnosed non‐invasively. Headache 36: 115–118.

Wall M and George D (1991) Idiopathic intracranial hypertension: a prospective study of 50 patients. Brain 114: 155–180.

Weisberg LA (1975) Benign intracranial hypertension. Medicine 54: 197–207.

Winner P and Bello L (1996) Idiopathic intracranial hypertension in a young child without visual symptoms or signs. Headache 36: 574–576.

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How to Cite close
Speed, William G(Mar 2002) Benign Intracranial Hypertension. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002200]