Memory: Clinical Disorders

Abstract

There are different forms of memory in the brain that use distinct anatomical structures to process various types of information in a variety of ways. Many disease processes can disrupt one or more of these forms of memory.

Keywords: memory; memory systems; Alzheimer disease

Figure 1.

The six basic forms of memory.

Figure 2.

The Papez circuit. Key components include the hippocampal formation, the fornix, the mammillary bodies (M), the anterior nucleus of the thalamus (AN), the cingulate gyrus and the presubiculum.

Figure 3.

Ribot's law. The injury can be due to any of the disorders described above, including the pathological changes of Alzheimer disease. The period of retrograde amnesia can last anywhere from several hours (in the case of transient global amnesia) to several years (in the case of surgical excision of the temporal lobes).

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References

Bechara A, Tranel D, Damasio H, et al. (1995) Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 269: 115–118.

Budson AE, Daffner KR, Desikan R and Schacter DL (2000) When false recognition is unopposed by true recognition: Gist based memory distortion in Alzheimer's disease. Neuropsychology 14: 277–287.

Budson AE, Simons JS, Sullivan AL, et al. (2004) Memory and emotions for the September 11, 2001, terrorist attacks in patients with Alzheimer's disease, patients with mild cognitive impairment, and healthy older adults. Neuropsychology 18: 315–327.

Damasio H, Grabowski TJ, Tranel D, Hichwa RD and Damasio AR (1996) A neural basis for lexical retrieval. Nature 380: 499–505.

Glisky EL and Schacter DL (1989) Extending the limits of complex learning in organic amnesia: computer training in a vocation domain. Neuropsychologia 27: 173–178.

Green JD and Hodges JR (1996) Identification of famous faces and famous names in early Alzheimer's disease. Relationship to anterograde episodic and general semantic memory. Brain 119: 111–128.

Owen AM, Sahakian BJ and Robbins TW (1998) The role of executive deficits in memory disorders in neurodegenerative disease. In: Troster AI (ed.) Memory in Neurodegenerative Disease: Biological, Cognitive, and Clinical Perspectives, pp. 157–171. Cambridge, UK: Cambridge University Press

Salmon DP, Lineweaver TT and Heindel WC (1998) Nondeclarative memory in neurodegenerative disease. In: Troster AI (ed.) Memory in Neurodegenerative Disease: Biological, Cognitive, and Clinical Perspectives, pp. 210–225. Cambridge, UK: Cambridge University Press

Schacter DL and Buckner RL (1998) Priming and the brain. Neuron 20: 185–195.

Schacter DL and Tulving E (1994) What are the memory systems of 1994?. In: Schacter DL and Tulving E (eds) Memory Systems 1994, pp. 1–38. Cambridge, MA: MIT Press

Schacter DL, Curran T, Galluccio L, Milberg W and Bates J (1996) False recognition and the right frontal lobe: a case study. Neuropsychologia 34: 793–808.

Simons JS and Spiers HJ (2003) Prefrontal and medial temporal lobe interactions in long‐term memory. Nature Reviews Neuroscience 4: 637–648.

Wagner AD, Schacter DL, Rotte M, et al. (1998) Building memories: remembering and forgetting of verbal experiences as predicted by brain activity. Science 281: 1188–1191.

Walker MP, Brakefield T, Hobson JA and Stickgold R (2003) Dissociable stages of human memory consolidation and reconsolidation. Nature 425: 616–620.

Further Reading

Feinberg TE and Farah MJ (1997) Behavioural Neurology and Neuropsychology. New York: McGraw‐Hill.

Gazzaniga M (2000) The New Cognitive Neurosciences. Cambridge, MA: MIT Press.

Perry RJ and Hodges JR (1996) Spectrum of memory dysfunction in degenerative disease. Current Opinion in Neurology 9: 281–285.

Schacter DL (1996) Searching for Memory: The Brain, the Mind, and the Past. New York: Basic Books.

Schacter DL (2001) The Seven Sins of Memory: How the Mind Forgets and Remembers. Boston: Houghton‐Mifflin.

Schacter DL and Tulving E (1994) Memory Systems 1994. Cambridge, MA: MIT Press.

Squire LR and Kandel ER (1999) Memory: From Mind to Molecules. New York: Scientific American Library.

Squire LR and Schacter DL (2002) Neuropsychology of Memory. New York: Guilford Press.

Troster AI (1998) Memory in Neurodegenerative Disease: Biological, Cognitive, and Clinical Perspectives. Cambridge, UK: Cambridge University Press.

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Budson, Andrew E, and Price, Bruce H(Sep 2005) Memory: Clinical Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0004052]