Epstein–Barr Virus and Cancer


Epstein–Barr virus is widespread in all human populations, and is usually carried as an asymptomatic persistent infection. In a small minority of infected individuals the virus is associated with the pathogenesis of certain types of lymphoid and nonlymphoid cancers, including Burkitt lymphoma, posttransplant lymphomas, Hodgkin disease and nasopharyngeal carcinoma.

Keywords: herpesvirus; lymphoma; carcinoma; hodgkin disease; transformation


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Further Reading

Heslop HE and Rooney CM (1997) Adoptive cellular immunotherapy for EBV lymphoproliferative disease. Immunological Reviews 157: 217–222.

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International Agency for Research on Cancer (1997) Epstein–Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 70. Lyon: IARC.

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Rickinson AB and Kieff E (1996) Epstein–Barr virus. In: Fields BN, Knipe DM, Howley PM et al. (eds) Fields Virology, 3rd edn, vol. 2, pp. 2397–2446. Philadelphia, PA: Lippincott‐Raven.

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Rowe, Martin, and Rickinson, AB(Apr 2001) Epstein–Barr Virus and Cancer. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002231]