Martin Rowe, University of Wales College of Medicine, Cardiff, UK
AB Rickinson, University of Birmingham, Birmingham, UK
Published online: April 2001
DOI: 10.1038/npg.els.0002231
Epstein–Barr virus is widespread in all human populations, and is usually carried as an asymptomatic persistent infection. In a small minority of infected individuals the virus is associated with the pathogenesis of certain types of lymphoid and nonlymphoid cancers, including Burkitt lymphoma, posttransplant lymphomas, Hodgkin disease and nasopharyngeal carcinoma.
Keywords: herpesvirus; lymphoma; carcinoma; hodgkin disease; transformation
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| Further Reading | |
| Heslop HE and Rooney CM (1997) Adoptive cellular immunotherapy for EBV lymphoproliferative disease. Immunological Reviews 157: 217–222. | |
| book International Agency for Research on Cancer (1996) "Human immunodeficiency viruses and human T-cell lymphotropic viruses". IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 67. Lyon: IARC. | |
| book International Agency for Research on Cancer (1997) "Epstein–Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8". IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 70. Lyon: IARC. | |
| book Kieff E (1996) "Epstein–Barr virus and its replication". In: Fields BN, Knipe DM, Howley PM et al. (eds) Fields Virology, 3rd edn, vol. 2, pp. 2343–2396. Philadelphia, PA: Lippincott-Raven. | |
| Klein G (1998) Post-transplantation lymphoproliferative disease. Springer Seminars in Immunopathology 20: 319–491. | |
| Niedobitek G and Young LS (1994) Epstein–Barr virus persistence and virus-associated tumours. Lancet 343: 333–335. | |
| book Rickinson AB and Kieff E (1996) "Epstein–Barr virus". In: Fields BN, Knipe DM, Howley PM et al. (eds) Fields Virology, 3rd edn, vol. 2, pp. 2397–2446. Philadelphia, PA: Lippincott-Raven. | |
| Thorley-Lawson D, Miyashita E and Khan G (1996) Epstein–Barr virus and the B cell: that's all it takes. Trends in Microbiology 4: 204–208. | |
| Zeng Y (1985) Seroepidemiological studies on nasopharyngeal carcinoma in China. Advances in Cancer Research 44: 121–138. | |
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