Parvovirus Infections in Humans


Parvoviruses are small, species‐specific DNA‐containing viruses that infect several animal species. The human parvoviruses include two agents, B19 virus and adeno‐associated virus; B19 virus causes several disease syndromes and is a medically important pathogen.

Keywords: parvovirus; B19 virus; erythema infectiosum


Anderson MJ, Higgins PG, Davis LR et al. (1985) Experimental parvoviral infection in humans. Journal of Infectious Diseases 152: 257–265.

Bansal GP, Hatfield JA, Dunn FE et al. (1993) Candidate recombinant vaccine for human B19 parvovirus. Journal of Infectious Diseases 167: 1034–1044.

Blacklow NR (1988) Adeno‐associated viruses of humans. In: Pattison JR (ed.) Parvoviruses and Human Diseases, pp. 165–174. Boca Raton, FL: CRC Press

Bostic JR, Brown KE, Young NS and Koenig S (1999) Quantitative analysis of neutralizing immune responses to human parvovirus B19 using a novel reverse transcriptase‐polymerase chain reaction‐based assay. Journal of Infectious Diseases 179: 619–626.

Brown KE, Hibbs JR, Gallinella G et al. (1994) Resistance to parvovirus B19 due to lack of virus receptor (erythrocyte P antigen). New England Journal of Medicine 330: 1192–1196.

Deiss V, Tratschin JD, Weitz M and Siegl G (1990) Cloning of the human parvovirus B19 genome and structural analysis of its palindromic termini. Virology 175: 247–254.

Kurtzman G, Frickhofen N, Kimball J et al. (1989) Pure red‐cell aplasia of 10 years’ duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. New England Journal of Medicine 321: 519–523.

Miller E, Fairley CK, Cohen BJ and Seng C (1998) Immediate and long term outcome of human parvovirus B19 infection in pregnancy. British Journal of Obstetrics and Gynaecology 105: 174–178.

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Siegl G and Cassinotti P (1998) Presence and significance of parvovirus B19 in blood and blood products. Biologicals 26: 89–94.

Valeur‐Jensen AK, Pedersen CB, Westergaard T et al. (1999) Risk factors for parvovirus B19 infection in pregnancy. JAMA 281: 1099–1105.

Further Reading

Anderson LJ and Young NS (eds) (1997) Human parvovirus B19. Monographs in Virology 20.

Centers for Disease Control (1989) Risks associated with human parvovirus B19 infection. Morbidity and Mortality Weekly Report 38: 81–97.

Harris JW (1992) Parvovirus B19 for the hematologist. American Journal of Hematology 39: 119–129.

Morey AL, Keeling JW, Porter HJ and Fleming KA (1992) Clinical and histopathological features of parvovirus B19 infection in the human fetus. British Journal of Obstetrics and Gynaecology 99: 566–574.

Naides SJ, Scharosch LI, Foto F and Howard EJ (1990) Rheumatologic manifestations of human parvovirus B19 infection in adults: initial two‐year clinical experience. Arthritis and Rheumatism 33: 1297–1309.

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Blacklow, Neil R(Jan 2003) Parvovirus Infections in Humans. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0002242]