Iron Overload and Chelation Therapy


Iron overload (haemochromatosis) is a disorder of iron metabolism commonly due to hereditary haemochromatosis or chronic transfusions. Chelation is the only available treatment for transfusional iron overload.

Keywords: iron; haemochromatosis; chelation; transfusions; ferritin


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Feder NJ, Penny DM, Irrinki A et al. (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proceedings of the National Academy of Sciences of the USA 95: 1472–1477.

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Further Reading

Bonkovsky HL (1991) Iron and the liver. American Journal of Medical Science 301: 32–43.

Nielsen P, Carpinteiro S, Fischer R et al. (1998) Prevalence of the C282Y and H63D mutations in the HFE gene in patients with hereditary haemochromatosis and in control subjects from northern Germany. British Journal of Haematology 103(3): 842–845.

Pippard MJ (1987) Iron overload and iron chelation therapy in thalassaemia and sickle cell haemoglobinopathies. Acta Haematologica 78: 206–211.

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How to Cite close
Bridges, Kenneth R(Apr 2001) Iron Overload and Chelation Therapy. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0002278]