Kidney and Renal Tract: Developmental Disorders


Kidney and urinary tract developmental disorders represent one of the most common groups of malformations, corresponding to approximately 30% of all malformations detected by antenatal ultrasonography in humans.

Keywords: kidney; development; malformation; genetics; inherited disorders

Figure 1.

Scheme of kidney morphogenesis. Mesenchyme/ureteric bud interactions and nephrogenesis. Successive phases are illustrated. (a) Metanephric mesenchyme/Wolffian duct interactions. (b) Mesenchyme (M)/ureteric bud (UB) interactions. GDNF, glial cell line‐derived neurotrophic factor. (c) Formation of cell condensates (C) at the branch points of UB. (d) Nephrogenesis. 1, condensates; 2, comma‐shaped bodies (polarized condensates); 3, the primitive nephron (N) forms specialized glomerular (G) and tubular epithelia and fuses with UB which itself has differentiated into collecting ducts (CD). (Adapted from Woolf and Winyard, 1998, and from Vainio and Müller, ).



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Grünfeld, Jean‐Pierre, and Salomon, Rémi(Jan 2006) Kidney and Renal Tract: Developmental Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0004196]