Constance R Chu, Brigham and Women's Hospital, Boston, Massachusetts, USA
Thomas S Thornhill, Brigham and Women's Hospital, Boston, Massachusetts, USA
Published online: April 2001
DOI: 10.1038/npg.els.0002309
Osteoarthritis is a pathological condition of articular cartilage and its underlying bone associated with biomechanical abnormalities and secondary inflammation. These changes result in cartilage loss, subchondral sclerosis, cyst and osteophyte formation, and the clinical sequelae of pain, swelling, deformity and loss of motion in affected joints.
Keywords: ageing; articular cartilage; cartilage transplantation; osteoarthritis; total joint replacement
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