Blood Cell: Lineage Restriction


Blood cell lineage restriction is a series of processes by which different blood cell lineages are produced from a population of multipotential cells. These processes involve cell proliferation and cell differentiation and are believed to repeat early embryonic processes of blood cell formation.

Keywords: erythrocytes; myeloid; haemangioblasts; stem cell; ventral mesoderm; platelets; macrophages; granulocytes; GATA; FOG; cytokines; SCL; VEGF; TGF‐β; BMP‐4

Figure 1.

Overview of blood cell lineages. All blood cells are derivatives of haematopoietic stem cells. The ventral mesoderm of a developing vertebrate embryo gives rise to blood stem cells. These cells differentiate and proliferate, forming different cell types that perform specialized functions. During this process, the pluripotent nature of stem cells is gradually restricted to a particular cell fate. Each blood cell lineage proliferates in a particular cytokine environment and different transcription factors regulate the lineage program.

Figure 2.

Details of cell lineages showing where transcription factor knockouts and natural mutations arrest development. Various transcription factors are required at certain stages of blood cell lineage specification. Genetic disruption of a transcription factor gene in mice can specifically eliminate a specific cell lineage.



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Further Reading

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Zhou, Yi, and Zon, Leonard I(Apr 2001) Blood Cell: Lineage Restriction. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0002324]