Signal Transduction Pathways in Development: Hedgehog Proteins and their Receptors
Marcel van den Heuvel, MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
Published online: April 2001
DOI: 10.1038/npg.els.0002329
Abstract
The Hedgehog proteins comprise a family of secreted signalling proteins of crucial importance for development of metazoan
animals. The signalling pathway downstream of Hedgehog proteins is highly conserved in evolution. Loss or misactivation of
the Hh signalling pathway can lead to pathogenesis.
Keywords: hedgehog; development; signal transduction
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