Posttranslational Processing: Peptide Hormones and Neuropeptide Transmitters

Abstract

The regulatory peptides that act as hormones, paracrine messengers or neurotransmitters are generally synthesized initially as large, inactive precursors that are converted to their active forms by a variety of different posttranslational processing steps including cleavage of the peptide chain and modification to individual residues for example by sulfation, phosphorylation, glycosylation and COOH‐terminal amidation.

Keywords: regulatory peptides; prohormone convertases; amidation; sulfation; secretory pathway

References

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Further Reading

Autelitano DJ, Rajic A, Smith AI et al. (2006) The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discovery Today 11: 306–314.

Cole LA and Khanlian SA (2007) Hyperglycosylated hCG: a variant with separate biological functions to regular hCG. Molecular and Cellular Endocrinology 260‐262: 228–236.

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Wilkinson CW (2006) Roles of acetylation and other post‐translational modifications in melanocortin function and interactions with endorphins. Peptides 27: 453–471.

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How to Cite close
Varro, Andrea(Dec 2007) Posttranslational Processing: Peptide Hormones and Neuropeptide Transmitters. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0002697.pub2]