Chargaff, Erwin


1905– Austrian‐born American biochemist whose discovery of the equality in quantity between certain bases in DNA (Chargaff's first parity rule) led to the Watson–Crick model.

Keywords: base composition; cluster rule; DNA; GC rule; parity rules

Figure 1.

Chargaff, Erwin. Courtesy of the National Library of Medicine.


Further Reading

Chargaff E (1951) Structure and function of nucleic acids as cell constituents. Federation Proceedings 10: 654–659.

Chargaff E (1963) Essays on Nucleic Acids. Amsterdam: Elsevier.

Chargaff E (1978) Heraclitean Fire. Sketches from a Life before Nature. New York: Rockefeller University Press.

Chargaff E (1979) How genetics got a chemical education. Annals of the New York Academy of Sciences 325: 345–360.

Chargaff E (1980) In praise of smallness. How can we return to small science? Perspectives in Biology and Medicine 23: 371–385.

Avery OT, MacLeod CM and McCarty M (1944) Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from Pneumococcus type III. Journal of Experimental Medicine 79: 137–158.

Forsdyke DR (1999) Two levels of information in DNA: relationship of Romanes’ ‘intrinsic’ variability of the reproductive system, and Bateson's ‘residue’ to the species‐dependent component of the base composition, (C+G)%. Journal of Theoretical Biology 201: 47–61.

Forsdyke DR (2001) The Origin of Species, Revisited. Montreal, Canada: McGill‐Queen's University Press.

Forsdyke DR Bioinformatics (Genomics) [∼forsdyke/bioinfor.htm]

Forsdyke DR Peer Review [∼forsdyke/peerrev.htm]

Forsdyke DR and Mortimer JR (2000) Chargaff's legacy. Gene 261: 127–137.

Olby R (1974) The Path to the Double Helix. Seattle: University of Washington Press.

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How to Cite close
Forsdyke, Donald R(Feb 2002) Chargaff, Erwin. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0002751]