Claude, Albert


Albert Claude (1899–1983) made major contributions to the understanding of the living cell's architecture in the 1940s, and even more importantly, to devising the methodological approach on which the discipline of cell biology is founded. This approach is marked by the coordinated use of independent experimental techniques, especially the separation of cellular components from homogenised tissue by means of high speed centrifugation, so that each of the centrifuge‐isolated cell fractions can be separately studied biochemically, and the use of the electron microscope to locate these components in native cell structure.

Key Concepts:

  • The field of cell biology depends upon the coordinated application of several independent experimental methods, especially the use of fractionation biochemistry to characterise the function of cell components and the use of electron microscopy to determine their location in the cell.

Keywords: cell biology; electron microscopy; endoplasmic reticulum; mitochondrion; protein synthesis; Rockefeller Institute; ultracentrifuge


Amsterdamska O (1993) From pneumonia to DNA: the research career of Oswald T. Avery. Historical Studies in the Physical and Biological Sciences 24: 1–40.

Bechtel W (1993) Integrating sciences by creating new disciplines: the case of cell biology. Biology & Philosophy 8: 277–299.

Brauckmann S (2006) A network of tissue cultures and cells: the American Society of Cell Biology. Archives Internationales d'Histoire des Sciences 56: 295–330.

Claude A (1950) Studies on cells: morphology, chemical constitution, and distribution of biochemical function. Harvey Lectures 43: 121–164.

de Duve C and Palade GE (1983) Albert Claude, 1899–1983. Nature 304: 588.

Elzen B (1986) Two ultracentrifuges: a comparative study of the social construction of artefacts. Social Studies of Science 16: 621–662.

Kay LE (1986) W. M. Stanley's crystallization of the Tobacco Mosaic Virus, 1930–1940. Isis 77: 450–472.

Palade GE (1971) Albert Claude and the beginnings of biological electron microscopy. Journal of Cell Biology 50: 5–19.

Rasmussen N (1995) Mitochondrial structure and the practice of cell biology in the 1950s. Journal of the History of Biology 28: 381–429.

Rasmussen N (1997) Picture Control: The Electron Microscope and the Transformation of Biology in America, 1940–1960. Stanford, CA: Stanford University Press.

Ravin A (1977) The gene as catalyst, the gene as organism. Studies in the History of Biology 1: 1–45.

Rheinberger H‐J (1995) From microsomes to ribosomes: “strategies” of “representation”. Journal of the History of Biology 28: 49–89.

Further Reading

Bechtel W (2008) Discovering Cell Mechanisms: The Creation of Modern Cell Biology. Cambridge: Cambridge University Press.

Fruton JF (1999) Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology. New haven, CT: Yale University Press.

Kay LE (1996) The Molecular Vision of Life: Caltech, the Rockefeller Foundation, and the Rise of the New Biology. Oxford: Oxford University Press.

Morange M (2000) A History of Molecular Biology. Cambridge, MA: Harvard University Press.

Olby R (1994) The Path to the Double Helix: The Discovery of DNA, rev. edn. New York, NY: Dover.

Rheinberger HJ (1997) Toward a History of Epistemic Things: Synthesizing Proteins in the Test Tube. Palo Alto, CA: Stanford University Press.

Summers WC (1999) Félix d'Herelle and the Origins of Molecular Biology. New Haven, CT: Yale University Press.

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Rasmussen, Nicolas(Nov 2014) Claude, Albert. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0002752]