Hitchings, George Herbert


1905–1998 American pharmacologist who, together with his long‐standing collaborator Gertrude Elion, introduced many new drugs, including 6‐mercaptopurine and azathioprine, and developed a rational approach to drug design.

Keywords: pharmacologist; Gertrude Elion; Nobel Prize; rational drug design; cancer; autoimmune diseases; nucleic acids; DNA; 6‐mercaptopurine (6MP); leukaemia; azathioprine (Imuran); rheumatoid arthritis; Zovirax; AZT

Further Reading

George KH (1995) George H. Hitchings (1905–): American pharmacologist. In: Murray EJ (ed.) Notable Twentieth‐Century Scientists, vol. 1. pp. 933–934. Detroit, MI: Gale Group.

Giner‐Sorolla A (1988) The excitement of a suspense story, the beauty of a poem: the work of Hitchings and Elion. Trends in Pharmacological Sciences 9: 437–438.

Hitchings GH (1980) Relevance of basic research to pharmaceutical invention. Trends in Pharmacological Sciences 1: 167–168.

Hitchings GH (1983) Rational design of anticancer drugs: here, imminent, or illusive? In: Cheng Y‐C (ed.) The Development of Target‐Oriented Anticancer Drugs, pp. 227–238. Raven Press, New York.

Hitchings GH (1998) In: American Men and Women of Science, vol. 3. pp. 874–875. New Providence, R R Bowker.

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Quirke, Viviane(Feb 2002) Hitchings, George Herbert. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002828]