Jerne, Niels Kaj

1911–1994 Danish immunologist who proposed a selection theory of antibody formation, the functional network of antibodies and lymphocytes and distinction of self from nonself by T lymphocytes.

Keywords: antibody avidity; natural selection theory of antibody formation; idiotypic network theory; haemolytic plaque assay

 Further Reading
    Jerne NK (1955) The natural selection theory of antibody formation. Proceedings of the National Academy of Sciences of the USA 41: 849.
    Jerne NK (1960) Immunological speculations. Annual Review of Microbiology 14: 341–358.
    book Jerne NK (1966) "The natural selection theory of antibody formation; ten years later". In: Cairns J, Stent GS and Watson JD (eds) Phage and the Origins of Molecular Biology, pp. 301–312. Cold Spring Harbor: Cold Spring Harbor Laboratory of Quantitative Biology.
    Jerne NK (1974) Towards a network theory of the immune system. Annals of Immunology 125C: 373–389.
    Jerne NK (1985) The generative grammar of the immune system. Science 229: 1057–1059.
    Jerne NK, Henry C, Nordin AA et al. (1974) Plaque forming cells: Methodology and theory. Transplantation Reviews 18: 130–191.
    book Greene MI and Nisonoff A (eds) (1984) The Biology of Idiotypes. New York: Plenum Press.
    book Köhler H (1984) "The immune network revisited". In: Köhler H, Urbain J and Cazenave P-A (eds) Idiotypy in Biology and Medicine, pp. 3–14. Orlando: Academic Press.
    book Silverstein AM (1989) A History of Immunology. San Diego: Academic Press.
    book Steinberg CM and Lefkovits I (eds) (1981) The Immune System. 1. Past and Future, 2. The Present. Festschrift in honor of Niels Kaj Jerne on the occasion of his 70th birthday. Basel: Karger.
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How to Cite close
Cruse, JM, and Lewis, RE(May 2001) Jerne, Niels Kaj. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0002838]