Protein Sequence Databases


The comprehensive, annotated and curated protein sequence databases – the PIR‐International Protein Sequence Database and SWISS‐PROT – support genome annotation, protein functional and structural analysis, proteomics, and phylogenetic studies. The databases are widely available, either free or by subscription, and are augmented by a variety of useful tools and related databases.

Keywords: protein sequences; sequence databases; bioinformatics resources; protein superfamilies

Further Reading

Bairoch A and Apweiler R (2000) The SWISS‐PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Research 28: 45–48.

Barker WC, Garavelli JS, Huang H et al. (2000) The Protein Information Resource (PIR). Nucleic Acids Research 28: 41–44.

Barker WC, Pfeiffer F and George DG (1996) The superfamily classification in the PIR‐International Protein Sequence Database. Methods in Enzymology 266: 59–71.

Garavelli JS (2000) The RESID Database of protein structure modifications: 2000 update. Nucleic Acids Research 28: 209–211.

Hofmann K, Bucher P, Falquet L and Bairoch A (1999) The PROSITE database, its status in 1999. Nucleic Acids Research 27: 215–219.

Nucleic Acids Research (2001) 29(1) [January 2001 special database issue]

Srinivasarao GY, Yeh LS, Marzec CR et al. (1999) Database of protein sequence alignments: PIR‐ALN. Nucleic Acids Research 27: 284–285.

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How to Cite close
Barker, Winona C(Apr 2001) Protein Sequence Databases. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0003029]