Protein Design


Protein design is the engineering of natural amino acid sequences to modify and/or create desired protein structures or functions.

Keywords: protein; inverse folding; sequence sampling; automated design; molecular evolution


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Further Reading

DeGrado WF, Wasserman ZR and Lear JD (1989) Protein design, a minimalist approach. Science 243: 622–628.

DeGrado WF, Summa CM, Pavone V, Nastri F and Lombardi A (1999) De novo design and structural characterization of proteins and metalloproteins. Annual Review of Biochemistry 68: 779–819.

Desjarlais JR and Clarke ND (1998) Computer search algorithms in protein modification and design. Current Opinion in Structural Biology 8: 471–475.

Gordon DB, Marshall SA and Mayo SL (1999) Energy functions for protein design. Current Opinion in Structural Biology 9: 509–513.

Lacroix E and Serrano L (2000) The EMBL Protein Design Unit. [http://ProteinDesign.EMBL-Heidelberg.DE]

Petrounia IP and Arnold FH (2000) Designed evolution of enzymatic properties. Current Opinion in Biotechnology 11: 325–330.

Street AG and Mayo SL (1999) Computational protein design. Structure with Folding and Design 7: R105–109.

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How to Cite close
Lacroix, Emmanuel, and Serrano, Luis(Apr 2001) Protein Design. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0003034]