Protein Tertiary Structures: Prediction from Amino Acid Sequences

Hongyu Zhang, Celera Genomics, Rockville, Maryland, USA

Published online: April 2002

DOI: 10.1038/npg.els.0003040

Protein tertiary structures contain key information for the understanding of the relationship between protein amino acid sequences and their biological functions. A large collection of computational algorithms has been developed to predict protein tertiary structures from their sequences in computers.

Keywords: protein structure prediction; protein folding; homology modelling; threading; ab initio prediction; Hidden Markov Model; structure genomics

Figure 1. Procedure for predicting a protein structure from its amino acid sequence.
Figure 2. Schematic view of ab initio prediction methods (revised from Lin, 1996).
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Related Sub-Topics:

Protein Structure | Protein Folding, Evolution and Degradation | Bioinformatics | Proteins: Structure, Function, Metabolism
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Article Title: Protein Tertiary Structures: Prediction from Amino Acid Sequences
 
How to Cite close
Zhang, Hongyu(Apr 2002) Protein Tertiary Structures: Prediction from Amino Acid Sequences. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003040]