Classical genetics has its origin in the 1850s and 1860s, when the Moravian monk Gregor Mendel attempted to formalize the rules of inheritance governing plant hybridization. When Mendel's laws were rediscovered in 1900, breeding experiments were wedded to cytological observation of chromosomes in the nucleus of organisms – most notably in the fruit fly – and classical genetics was born, culminating towards mid-century in models of what genes do, and what they are made of.