Vitamin B2 Deficiency


The consequences of vitamin B2 deficiency can be far reaching. In humans it can lead to weakness and fatigue and can influence drug and lipid metabolism.

Keywords: riboflavin; flavin coenzymes; FMN; FAD; glutathione


Capo‐chichi CD, Gueant J‐L, LeFebvre E et al. (1999) Riboflavin and riboflavin‐derived cofactors in adolescent girls with anorexia nervosa. American Journal of Clinical Nutrition 69: 672–678.

Chaistain JL and McCormick DB (1987) Flavin catabolites: identification and quantitation in human urine. American Journal of Clinical Nutrition 46: 830–834.

Cimino JA, Jhangiani S, Schwartz E et al. (1987) Riboflavin metabolism in the hypothyroid human adult. Proceedings of the Society for Experimental Biology and Medicine 184: 151–153.

Dutta P, Gee M, Rivlin RS and Pinto JT (1988) Riboflavin deficiency and glutathione metabolism: possible mechanisms underlying altered responses to homolytic stimuli. Journal of Nutrition 118: 1149–1157.

Goldsmith GA (1975) Riboflavin deficiency. In: Rivlin RS (ed.) Riboflavin, pp. 221–242. New York: Plenum Press

Kalter H and Warkany J (1957) Congenital malformations in inbred strains of mice induced by riboflavin‐deficient, galactoflavin‐containing diets. Journal of Experimental Zoology 136: 531–565.

McCormick DB (1989) Two interconnected B vitamins: riboflavin and pyridoxine. Physiological Reviews 69: 1170–1198.

McCormick DB (1994) Riboflavin. In: Shils ME, Olson JA and Shike M (eds) Modern Nutrition in Health and Disease, 8th ed. pp. 366–375. Philadelphia: Lea and Febiger

Pinto JT, Huang YP and Rivlin RS (1981) Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. Journal of Clinical Investigation 67: 1500–1506.

Rivlin RS (1991) Disorders of vitamin metabolism: deficiencies, metabolic abnormalities and excesses. In: Wyngaarden JH, Smith LH Jr, Bennett JC and Plum F (eds) Cecil Textbook of Medicine, 19th ed. pp. 1170–1183. Philadelphia: WB Saunders

Sauberlich HE, Judd JH, Nichoalds HP et al. (1972) Application of the erythrocyte glutathione reductase assay in evaluating riboflavin nutritional status in a high school population. American Journal of Clinical Nutrition 25: 756–762.

Tandler B, Erlandson RA and Wynder EL (1968) Riboflavin and mouse hepatic cell structure and function. I. Ultrastructural alterations in simple deficiency. American Journal of Pathology 52: 69–96.

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Rivlin, Richard S(Jan 2003) Vitamin B2 Deficiency. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0003278]