Vitamin B2 Deficiency

Abstract

The consequences of vitamin B2 deficiency can be far reaching. In humans it can lead to weakness and fatigue and can influence drug and lipid metabolism.

Keywords: riboflavin; flavin coenzymes; FMN; FAD; glutathione

References

Capo‐chichi CD, Gueant J‐L, LeFebvre E et al. (1999) Riboflavin and riboflavin‐derived cofactors in adolescent girls with anorexia nervosa. American Journal of Clinical Nutrition 69: 672–678.

Chaistain JL and McCormick DB (1987) Flavin catabolites: identification and quantitation in human urine. American Journal of Clinical Nutrition 46: 830–834.

Cimino JA, Jhangiani S, Schwartz E et al. (1987) Riboflavin metabolism in the hypothyroid human adult. Proceedings of the Society for Experimental Biology and Medicine 184: 151–153.

Dutta P, Gee M, Rivlin RS and Pinto JT (1988) Riboflavin deficiency and glutathione metabolism: possible mechanisms underlying altered responses to homolytic stimuli. Journal of Nutrition 118: 1149–1157.

Goldsmith GA (1975) Riboflavin deficiency. In: Rivlin RS (ed.) Riboflavin, pp. 221–242. New York: Plenum Press

Kalter H and Warkany J (1957) Congenital malformations in inbred strains of mice induced by riboflavin‐deficient, galactoflavin‐containing diets. Journal of Experimental Zoology 136: 531–565.

McCormick DB (1989) Two interconnected B vitamins: riboflavin and pyridoxine. Physiological Reviews 69: 1170–1198.

McCormick DB (1994) Riboflavin. In: Shils ME, Olson JA and Shike M (eds) Modern Nutrition in Health and Disease, 8th ed. pp. 366–375. Philadelphia: Lea and Febiger

Pinto JT, Huang YP and Rivlin RS (1981) Inhibition of riboflavin metabolism in rat tissues by chlorpromazine, imipramine and amitriptyline. Journal of Clinical Investigation 67: 1500–1506.

Rivlin RS (1991) Disorders of vitamin metabolism: deficiencies, metabolic abnormalities and excesses. In: Wyngaarden JH, Smith LH Jr, Bennett JC and Plum F (eds) Cecil Textbook of Medicine, 19th ed. pp. 1170–1183. Philadelphia: WB Saunders

Sauberlich HE, Judd JH, Nichoalds HP et al. (1972) Application of the erythrocyte glutathione reductase assay in evaluating riboflavin nutritional status in a high school population. American Journal of Clinical Nutrition 25: 756–762.

Tandler B, Erlandson RA and Wynder EL (1968) Riboflavin and mouse hepatic cell structure and function. I. Ultrastructural alterations in simple deficiency. American Journal of Pathology 52: 69–96.

Contact Editor close
Submit a note to the editor about this article by filling in the form below.

* Required Field

How to Cite close
Rivlin, Richard S(Jan 2003) Vitamin B2 Deficiency. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003278]