Reductionism in Biology

Explanatory and methodological reductionism in biology emphasizes the importance of building explanations and pursuing research at ever-deeper levels of organization. Explanatory and methodological integrationism, in contrast, emphasize the importance of building explanations and pursuing research at and between multiple levels of organization in hierarchically organized mechanisms. Some of the perceived advantages of reduction are reviewed, but it is noted that reductionist tendencies are prone to biases and distortions in the description of biological systems that can be removed with the simultaneous use of integrative research strategies. Integrationism is defined in terms of the search for multilevel mechanisms. Attention to such a multilevel perspective aids in avoiding the biases and distortions that reductionist strategies are prone to produce.

Key concepts

  • Reductionist research strategies have advantages in biology, whereas biases that they introduce can be countered by employing integrative strategies in the search for mechanisms at multiple levels.

Keywords: reduction; reductionism; integration; levels; mechanism

 References
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 Further Reading
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    book Bechtel W (2008) Mental Mechanisms: Philosophical Perspectives on Cognitive Neuroscience. New York: Routledge.
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    book Bechtel W and Richardson RC (1992) "Emergent phenomena and complex systems". In: Beckermann A, Flohr H and Kim J (eds) Emergence or Reduction? pp. 257–288. New York: W. de Gruyter.
    book Craver CF and Bechtel W (2006) "Mechanism". In: Sarkar S and Pfeifer J (eds) Philosophy of Science: An Encyclopedia, pp. 469–478. New York: Routledge.
    Craver CF and Bechtel W (2007) Top-down causation without top-down causes. Biology and Philosophy 22(4): 547–563.
    Darden L (2002) Strategies for discovering mechanisms: schema instantiation, modular subassembly, forward/backward chaining. Philosophy of Science 69: S354–S365.
    Darden L (2008) Thinking again about mechanisms. Philosophy of Science 75(5): 958–969.
    Darden L and Craver CF (2002) Strategies in the interfield discovery of the mechanism of protein synthesis. Studies in History and Philosophy of Biological and Biomedical Sciences 33: 1–28.
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    book Rosenberg A (2007) "Reductionism (and antireductionism) in biology". In: Hull DL and Ruse M (eds) Cambridge Companion to Philosophy of Biology, pp. 120–138. New York: Cambridge University Press.
    Schaffner K (2006) Reduction: the cheshire cat problem and a return to roots. Synthese 151(3): 377–402. (A special issue on Reduction and Emergence).
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 Web Links
    ePath Adaptationist Claims – Conceptual Problems http://mrw.interscience.wiley.com/emrw/9780470015902/els/article/a0003451/current/html#references
    ePath Caenorhabditis elegans as an Experimental Organism http://mrw.interscience.wiley.com/emrw/9780470015902/els/article/a0000564/current/html
    ePath Philosophy of Molecular Biology http://mrw.interscience.wiley.com/emrw/9780470015902/els/article/a0003448/current/html
    ePath Philosophy of Selection: Units and Levels http://mrw.interscience.wiley.com/emrw/9780470015902/els/article/a0003463/current/html
    ePath Philosophy of the Life Sciences http://mrw.interscience.wiley.com/emrw/9780470015902/els/article/a0003449/current/html
    ePath Reduction: A Philosophical Analysis http://mrw.interscience.wiley.com/emrw/9780470015902/els/article/a0003460/current/html
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Darden, Lindley, and Craver, Carl F(Sep 2009) Reductionism in Biology. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0003356]