Disease Eradication by Vaccination: Prospects

Eradication is the last step in the fight against pathogens and the cessation of their transmission. Several efficacious vaccines have contributed immensely to the reduction of incidence of many diseases, but only a few diseases are amenable to eradication. Bridging the health gap between developing and developed countries is being addressed through public–private partnerships and through governments’ financial commitment to vaccine programs. Vaccines as a health intervention, offer the best economic and social value against emerging and re-emerging diseases, and represent the best option for control, elimination and eradication of infectious pathogens. Novel and more potent vaccines could strengthen future eradication efforts.

Keywords: eradication; vaccination; control; transmission; infectious pathogen; technology

Figure 1. Polio case map update. Reproduced by permission of the World Health Organization. http://www.polioeradication.org/casecount.asp
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 References
    Brugha R, Starling M and Walt G (2002) GAVI, the first steps: lessons for the Global Fund. Lancet 359: 435–438.
    de Quadros CA (2006) Is global measles eradication feasible? Current Topics in Microbiology and Immunology 304: 153–163.
    Fauci AS (2001) Infectious diseases: considerations for the 21st century. Clinical Infectious Diseases 32: 675–685.
    Gréco M (2001) The future of vaccines: an industrial perspective. Vaccine 20: S101–S103.
    Kew OM, Wright PF, Agol VI et al. (2004) Circulating vaccine-derived polioviruses: current state of knowledge. Bulletin of the World Health Organization 82: 16–23.
    Kimman TG and Hein Boot (2006) The polio eradication effort has been a great success: let's finish it and replace it with something even better. The Lancet Infectious Diseases 6: 675–678.
    Lahariya C, Khandekar J and Pradhan SK (2006) Polio eradication: what do we do now?. Lancet 368: 732.
    Meissner HC, Strebel PM and Orenstein WA (2004) Measles vaccines and the potential for worldwide eradication of measles. Pediatrics 114: 1065–1069.
    Morens DM, Folkers GK and Fauci AS (2004) The challenge of emerging and re-emerging infectious diseases. Nature 430: 242–249.
 Further Reading
    Boot HJ, Kasteel DTJ, Buisman AM and Kimman TG (2003) Excretion of wild-type and vaccine-derived poliovirus in the feces of poliovirus receptor-transgenic mice. Journal of Virology 77: 6541–6545.
    CDC (2005) Imported vaccine-associated paralytic poliomyelitis–United States. MMWR Morbidity and Mortality Weekly Report 55: 97–99.
    CDC (2006) Progress in reducing global measles deaths, 1999–2004. MMWR Morbidity and Mortality Weekly Report 55: 247–249.
    Henderson DA (1980) Smallpox eradication. Public Health Reports 95: 422–426.
    book Plotkin SA (2006) Mass Vaccination: Global Aspects – Progress and Obstacles 1st edn. Springer.
    other WHO, Global eradication of polio by year 2000 (1988) Resolution WHA 41.28. Geneva.
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How to Cite close
Alloueche, A, Del Giudice, G, and Rappuoli, R(Jul 2007) Disease Eradication by Vaccination: Prospects. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0003386]