Whole Animal Cloning

Ian Wilmut, Roslin Institute, Roslin, Midlothian, UK

Published online: May 2003

DOI: 10.1038/npg.els.0003388

The new methods of nuclear transfer in mammals have already provided important understanding of the mechanisms that regulate development and have revealed new avenues for research and applications in medicine and agriculture. Improvements in the present low efficiency of the techniques will depend upon understanding the molecular mechanisms that govern gene expression during development and differentiation.

Keywords: cell therapy; nuclear transfer; genetic modification; nuclear reprogramming; chromatin

 References
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    Jaenisch R and Wilmut I (2001) Don’t clone humans! Science 291: 2552.
    Ogura A, Inoue K, Ogonuki N et al. (2000) Production of male cloned mice from fresh, cultured, and cryopreserved immature Sertoli cells. Biology of Reproduction 62: 1579–1584.
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    Schnieke AE, Kind AJ, Ritchie WA et al. (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278: 2130–2133.
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Related Sub-Topics:

Genes, Molecules and Cellular Processes | Developmental Disorders | Developmental Concepts | Cell Differentiation and Stem Cells | Gametogenesis and Fertilisation | Gene and Genome Structure and Organisation | Techniques and Tools in Clinical Genetics | Epigenetics and Disease | Techniques and Tools in Molecular Biology
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Article Title: Whole Animal Cloning
 
How to Cite close
Wilmut, Ian(May 2003) Whole Animal Cloning. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003388]