Ageing – Future Directions for Research in the Biology of Ageing

Thomas BL Kirkwood, University of Newcastle, Newcastle Upon Tyne, UK

Published online: May 2003

DOI: 10.1038/npg.els.0003394

An increasing fraction of the world's population is living to an age when intrinsic biological constraints take their toll on health and quality of life through age-related frailty. As the number of older people increases, so does the number suffering from a wide range of age-associated disabilities and diseases.

Keywords: ageing; senescence; longevity; genetics; stress

 References
    Austad SN (1993) Retarded senescence in an insular population of opossums. Journal of Zoology 229: 695–708.
    Brierley EJ, Johnson MA, Lightowlers RN, James OF and Turnbull DM (1998) Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Annals of Neurology 43: 217–223.
    Campisi J, Kim SH, Lim CS and Rubio M (2001) Cellular senescence, cancer and aging: the telomere connection. Experimental Gerontology 36: 1619–1637.
    Chiu CP and Harley CB (1997) Replicative senescence and cell immortality: the role of telomeres and telomerase. Proceedings of the Society for Experimental Biology and Medicine 214: 99–106.
    Cournil A and Kirkwood TBL (2001) If you would live long, choose your parents well. Trends in Genetics 17: 233–235.
    Dolle MET, Giese H, Hopkins CL, Martus HJ, Hausdorff JM and Vijg J (1997) Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nature Genetics 17: 431–434.
    book Finch CE and Kirkwood TBL (2000) Chance, Development and Aging. New York: Oxford University Press.
    Finch CE and Tanzi RE (1997) The genetics of aging. Science 278: 407–411.
    Grube K and Bürkle A (1992) Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific lifespan. Proceedings of the National Academy of Sciences of the USA 89: 11759–11763.
    Hawkes K, O'Connell JF, Jones NGB, Alvarez H and Charnov EL (1998) Grandmothering, menopause, and the evolution of human life histories. Proceedings of the National Academy of Sciences of the USA 95: 1336–1339.
    Kapahi P, Boulton ME and Kirkwood TBL (1999) Positive correlation between mammalian lifespan and cellular resistance to stress. Free Radical Biology and Medicine 26: 495–500.
    Kirkwood TBL and Austad SN (2000) Why do we age? Nature 408: 233–238.
    Kowald A and Kirkwood TBL (1996) A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutation Research 316: 209–236.
    Linnane AW, Marzuki S, Ozawa T and Tanaka M (1989) Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 25: 642–645.
    Lithgow GJ (1996) Invertebrate gerontology: the age mutations of Caenorhabditis elegans. BioEssays 18: 809–815.
    Martin GM, Austad SN and Johnson TE (1996) Genetic analysis of aging: role of oxidative damage and environmental stresses. Nature Genetics 13: 25–34.
    Ogburn CE, Austad SN, Holmes DJ, et al. (1998) Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage. Journal of Gerontology 53: B287–B292.
    Packer C, Tatar M and Collins A (1998) Reproductive cessation in female mammals. Nature 392: 807–811.
    Promislow DEL, Tatar M, Khazaeli AA and Curtsinger JW (1995) Age-specific patterns of genetic variation in Drosophila melanogaster. I. Mortality. Genetics 143: 839–848.
    Schächter FL, Faure-Delanef L, Geunot F, et al. (1994) Genetic associations with human longevity at the APOE and ACE loci. Nature Genetics 6: 29–32.
    Shanley DP and Kirkwood TBL (2001) Evolution of the human menopause. BioEssays 23: 282–287.
    Sohal RS, Ku H-H and Agarwal S (1993) Biochemical correlates of longevity in two closely-related rodent species. Biochemical and Biophysical Research Communications 196: 7–11.
    von Zglinicki T, Bürkle A and Kirkwood TBL (2001) Stress, DNA damage and ageing – an integrative approach. Experimental Gerontology 36: 1049–1062.
    Westendorp RGJ and Kirkwood TBL (1998) Human longevity at the cost of reproductive success. Nature 396: 743–746.
    Westendorp RGJ and Kirkwood TBL (1999) Human longevity and reproductive success: response to Gavrilov and Gavrilova. Journal of Anti-Aging Medicine 2: 125–126.
    Zwaan BJ, Bijlsma R and Hoekstra RE (1995) Direct selection on lifespan in Drosophila melanogaster. Evolution 49: 649–659.
 Further Reading
    book Austad SN (1997) Why We Age: What Science is Discovering about the Body's Journey Through Life. New York: John Wiley.
    book Arking R (1998) Biology of Aging: Observations and Principles, 2nd edn. Sunderland, MA: Sinauer.
    book Hayflick L (1996) How and Why We Age. New York: Ballantine Books.
    book Holliday R (1995) Understanding Ageing. Cambridge: Cambridge University Press.
    book Kirkwood T (1999) Time of Our Lives: the Science of Human Ageing. Oxford: Oxford University Press.

Related Sub-Topics:

Cell Death and Cellular Senescence | Human Evolution | General Genetics and Disease
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Article Title: Ageing – Future Directions for Research in the Biology of Ageing
 
How to Cite close
Kirkwood, Thomas BL(May 2003) Ageing – Future Directions for Research in the Biology of Ageing. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003394]