History of Fatty Acids


In the early years of the 20th century the major causes of death were infectious disease, however with introduction of better sanitation, cleaner food preparation and antibacterial drugs the major killers have become degenerative diseases such as heart disease and cancer. Investigating the metabolic role of fat (from synthesis to utilization) may be central to our understanding of the two major causes of death in the developed world, namely, heart disease and cancer.

Keywords: fatty acids; cholesterol; heart disease

Further Reading

Derr J, Kris‐Etherton PM, Pearson TA and Seligson FH (1993) The role of fatty acid saturation on plasma lipids, lipoproteins and apolipoproteins. II. The plasma total and low‐density cholesterol response to individual fatty acids. Metabolism 42: 130–134.

Keys A, Anderson JT and Grande F (1965) Serum cholesterol response to changes in diet. IV. Particular fatty acids in the diet. Metabolism 14: 776–787.

Kritchevsky D, Tepper SA, Kuksis A, Eghtedary K and Klurfield DM (1998) Cholesterol vehicle in experimental atherosclerosis. 21. Native and randomized lard and tallow. Journal of Nutrition and Biochemistry 9: 582–585.

Mattson FH and Grundy SM (1985) Comparison of effects of saturated, monounsaturated and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. Journal of Lipid Research 26: 194–202.

Mead JF, Alfin‐Slater RB, Howton DR and Popjak G (1986) Chemistry, biochemistry and nutrition. Lipids. New York: Plenum Press.

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How to Cite close
Kritchevsky, David(Jul 2002) History of Fatty Acids. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0003418]