Denaturation of RNA Using Glyoxal


RNA normally exhibits a high degree of secondary structure and aggregation. By treating RNA with glyoxal the RNA molecules can be completely denatured and assume random coil configurations.

Keywords: RNA; denaturation; glyoxal; electrophoresis

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Southern, Edwin M(Jul 2003) Denaturation of RNA Using Glyoxal. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0003789]