3′ UTRs and Regulation

Abstract

Messenger RNAs contain sequences that do not encode proteins and are not translated. These occur at the 5′ and 3′ ends of the coding region and are referred to as untranslated regions (UTRs). 3′ UTRs have various roles in the posttranscriptional control of gene expression.

Keywords: 3′ untranslated; mRNA degradation; mRNA localization; messenger RNA; posttranscriptional

Figure 1.

A proposed consensus structure for the selenocysteine insertion sequence found in the 3′ UTRs of selenoprotein genes (see Web Links).

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References

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Further Reading

Bergsten SE, Huang T, Chatterjee S and Gavis ER (2001) Recognition and long‐range interactions of a minimal nanos RNA localization signal element. Development 128: 427–435.

Dalgleish G, Veyrune J‐L, Blanchard J‐M and Hesketh JE (2000) mRNA localization by a 145 nt region of the c‐fos 3′ untranslated region: links to translation but not stability. Journal of Biology Chemistry 276: 13593–13599.

Gramolini AO, Belanger G and Jasmin BJ (2001) Distinct regions in the 3′ untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells. Journal of Cell Biology 154: 1173–1183.

Grzybowska EA, Wilczynska A and Siedlecki JA (2001) Regulatory functions of 3′ UTRs. Biochemical and Biophysical Research Communications 288: 291–295.

Kislauskis EH, Li Z, Taneja KL and Singer RH (1993) Isoform‐specific 3′ untranslated sequences sort α‐cardiac and β‐cytoplasmic actin messenger RNAs to different cytoplasmic compartments. Journal of Cell Biology 123: 165–172.

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Wagner C, Palacios I, Jeager L, et al. (2001) Dimerization of the 3′ UTR of bicoid mRNA involves a two‐step mechanism. Journal of Molecular Biology 313: 511–524.

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Web Links

UTR Database (UTRdb). 5′ and 3′ UTRs of eukaryotic mRNAs http://bighost.area.ba.cnr.it/BIG/UTRHome

Gladyshev website. Prediction of selenocysteine insertion motifs (SECIS) http://bio‐selenium.unl.edu

SECI Search website. Identification of SECIS elements. http://genome.unl.edu/SECISearch.html

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How to Cite close
Hesketh, John(Sep 2005) 3′ UTRs and Regulation. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005011]