Chromosomes 21 and 22: Comparisons


The size, patterns in base composition and gene density, number and kind of genes, disease association and trisomy are compared in chromosomes 21 and 22.

Keywords: chromosome 21; chromosome 22; genomic sequence


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Further Reading

Bailey JA, Gu Z, Clark RA, et al. (2002) Recent segmental duplications in the human genome. Science 297: 1003–1007.

Bailey JA, Yavor AM, Viggiano L, et al. (2002) Human‐specific duplication and mosaic transcripts: the recent paralogous structure of chromosome 22. American Journal of Human Genetics 70: 83–100.

Collins JE, Goward ME, Cole CG, et al. (2003). Reevaluating human gene annotation: a second‐generation alalysis of chromosome 22. Genome Research 13: 27–36.

Dawson E, Chen Y, Hunt S, et al. (2001) A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Research 11: 170–178.

Kehrer‐Sawatzki H, Wohr G, Schempp W, et al. (1998) Mapping of members of the low‐copy‐number repetitive DNA sequence family chAB4 within the p arms of human acrocentric chromosomes: characterization of Robertsonian translocations. Chromosome Research 6: 429–435.

Mullikin JC, Hunt SE, Cole CG, et al. (2000) An SNP map of human chromosome 22. Nature 407: 516–520.

Shiels C, Coutelle C and Huxley C (1997) Contiguous arrays of satellites 1, 3, and beta form a 1.5 Mb domain on chromosome 22p. Genomics 44: 35–44.

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How to Cite close
Dunham, Ian(Sep 2005) Chromosomes 21 and 22: Comparisons. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005015]