The size, patterns in base composition and gene density, number and kind of genes, disease association and trisomy are compared in chromosomes 21 and 22.
Keywords: chromosome 21; chromosome 22; genomic sequence
Chromosomes 21 and 22: Comparisons
Ian Dunham, The Sanger Institute, Hinxton, UK
Published online: September 2005
DOI: 10.1038/npg.els.0005015
| References | |
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| Further Reading | |
| Bailey JA, Gu Z, Clark RA, et al. (2002) Recent segmental duplications in the human genome. Science 297: 1003–1007. | |
| Bailey JA, Yavor AM, Viggiano L, et al. (2002) Human-specific duplication and mosaic transcripts: the recent paralogous structure of chromosome 22. American Journal of Human Genetics 70: 83–100. | |
| Collins JE, Goward ME, Cole CG, et al. (2003). Reevaluating human gene annotation: a second-generation alalysis of chromosome 22. Genome Research 13: 27–36. | |
| Dawson E, Chen Y, Hunt S, et al. (2001) A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence. Genome Research 11: 170–178. | |
| Kehrer-Sawatzki H, Wohr G, Schempp W, et al. (1998) Mapping of members of the low-copy-number repetitive DNA sequence family chAB4 within the p arms of human acrocentric chromosomes: characterization of Robertsonian translocations. Chromosome Research 6: 429–435. | |
| Mullikin JC, Hunt SE, Cole CG, et al. (2000) An SNP map of human chromosome 22. Nature 407: 516–520. | |
| Shiels C, Coutelle C and Huxley C (1997) Contiguous arrays of satellites 1, 3, and beta form a 1.5 Mb domain on chromosome 22p. Genomics 44: 35–44. | |
