Intronless Genes

Abstract

Most eukaryotic protein‐coding genes are composed of exon and intron sequences. Intron derived sequences within primary transcripts are eliminated by ribonucleic acid (RNA) splicing. A small number of protein‐coding genes are intronless; their primary transcripts are processed at their 5′ and 3′ ends like other premessenger RNAs, but no splicing is needed. Examples of intronless genes are genes for histone and interferon.

Keywords: introns; intronless genes; retroposons; histones; histone genes

References

Albig W and Doenecke D (1997) The human histone gene cluster at the D6S105 locus. Human Genetics 101: 284–294.

Albig W, Kioschis P, Poustka A, Meergans K and Doenecke D (1997) Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314–322.

Brosius J (1991) Retroposons: seeds of evolution. Science 252: 753.

Cavalier‐Smith T (1991) Intron phylogeny: a new hypothesis. Trends in Genetics 7: 145–148.

Chaboute MH, Chaubet N, Gigot C and Philipps G (1993) Histones and histone genes in higher plants. Biochimie 75: 523–531.

Gentles AJ and Karlin S (1999) Why are human G‐protein coupled receptors predominantly intronless? Trends in Genetics 15: 47–49.

Gilbert W (1978) Why genes in pieces? Nature 271: 501.

Glusman G, Sosinsky A, Ben‐Asher E, et al. (2000) Sequence, structure and evolution of a complete human olfactory receptor gene cluster. Genomics 63: 227–245.

Hentschel CC and Birnstiel ML (1981) The organization and expression of histone gene families. Cell 25: 301–313.

Roberts RM, Liu L, Guo Q, Leaman D and Bixby J (1998) The evolution of the type I interferons. Journal of Interferon and Cytokine Research 18: 805–816.

Further Reading

De Maeyer E and De Maeyer‐Guignard J (1998) Type I interferons. International Review of Immunology 17: 53–73.

Doenecke D, Albig W, Bouterfa H and Drabent B (1994) Organization and expression of H1 histone and H1 replacement histone genes. Journal of Cellular Biochemistry 54: 423–431.

Dohlman HG, Caron MG and Lefkowitz RJ (1987) A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry 26: 2657–2664.

Gilbert W and Glynias M (1993) On the ancient nature of introns. Gene 135: 137–144.

Graham JG (1995) Tandem genes and clustered genes. Journal of Theoretical Biology 175: 71–87.

Maxson R, Cohn R, Kedes L and Mohun T (1983) Expression and organization of histone genes. Annual Reviews of Genetics 17: 239–277.

Missale C, Nash SR, Robinson SW, Jaber M and Caron MG (1998) Dopamine receptors: from structure to function. Physiological Reviews 78: 189–225.

Probst WC, Snyder LA, Schuster DI, Brosius J and Sealfon SC (1992) Sequence alignment of the G‐protein‐coupled receptor superfamily. DNA Cell Biology 11: 1–20.

Stoltzfus A, Logsdon JM, Palmer JD and Doolittle WF (1997) Intron sliding and the diversity of intron positions. Proceedings of the National Academy of Sciences of the United States of America 94: 10739–10744.

Wang ZF, Whitfield ML, Ingledue TC, Dominsky Z and Marzluff WF (1996) The protein that binds the 3′ end of histone mRNA: a novel RNA‐binding protein required for histone pre‐mRNA processing. Genes and Development 10: 3028–3040.

Web Links

H1 histone family, member 0 (H1F0); Locus ID: 3005. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3005

H1 histone family, member T (testis‐specific) (H1FT); Locus ID: 3010. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3010

H2A histone family, member Y (H2AFY); Locus ID: 9555. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=9555

H3 histone, family 3A (H3F3A); Locus ID: 3020. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3020

H1 histone family, member 0 (H1F0); MIM number: 142708. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?142708

H1 histone family, member T (testis‐specific) (H1FT); MIM number: 142712. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?142712

H3 histone, family 3A (H3F3A); MIM number: 601128. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?601128

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How to Cite close
Doenecke, Detlef, and Albig, Werner(Sep 2005) Intronless Genes. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005022]