Signal peptides are parts of polypeptide chains that are used as ‘address labels’ for sorting proteins to their correct subcellular destinations.
Keywords: signal peptide; protein sorting; secretion; targeting; organelle
Signal Peptides
Gunnar von Heijne, Stockholm University, Stockholm, Sweden
Published online: September 2005
DOI: 10.1038/npg.els.0005050
| References | |
| Abe Y, Shodai T, Muto T, et al. (2000) Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell 100: 551–560. | |
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| Further Reading | |
| Bayliss R, Corbett A and Stewart M (2000) The molecular mechanism of transport of macromolecules through nuclear pore complexes. Traffic (Copenhagen, Denmark) 1: 448–456. | |
| Fujiki Y (2000) Peroxisome biogenesis and peroxisome biogenesis disorders. FEBS Letters 476: 42–46. | |
| Görlich D and Kutay U (1999) Transport between the cell nucleus and the cytoplasm. Annual Review of Cell and Developmental Biology 15: 607–660. | |
| Johnson AE and Haigh NG (2000) The ER translocon and retrotranslocation: is the shift into reverse manual or automatic? Cell 102: 709–712. | |
| Kornfeld S and Mellman I (1989) The biogenesis of lysosomes. Annual Review of Cell Biology 5: 483–525. | |
| Matlack K, Mothes W and Rapoport T (1998) Protein translocation: tunnel vision. Cell 92: 381–390. | |
| Pelham HR (1996) The dynamic organization of the secretory pathway. Cell Structure and Function 21: 413–419. | |
| Sacksteder KA and Gould SJ (2000) The genetics of peroxisome biogenesis. Annual Review of Genetics 34: 623–652. | |
| Voos W, Martin H, Krimmer T and Pfanner N (1999) Mechanisms of protein translocation into mitochondria. Biochimica et Biophysica Acta – Biomembranes 1422: 235–254. | |
