Exons: Shuffling


Exon shuffling through recombination in spliceosomal introns had a major role in the evolution of multidomain proteins associated with multicellularity of metazoa.

Keywords: intronic recombination; chimeric gene; exon duplication; exon insertion; spliceosomal intron


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Further Reading

Doolittle WF (1978) Genes in pieces: were they ever together? Nature 272: 581–582.

Logsdon JM (1998) The recent origins of spliceosomal introns revisited. Current Opinion in Genetics & Development 8: 637–648.

Patthy L (1995) Protein Evolution by Exon Shuffling. New York: Springer.

Patthy L (1999, 2007) Protein Evolution. Oxford, UK: Blackwell Science.

Sharp PA (1985) On the origin of RNA splicing and introns. Cell 42: 397–400.

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How to Cite close
Patthy, László(Apr 2008) Exons: Shuffling. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005087.pub2]