Gross Insertions and Microinsertions in Evolution


Gross insertions and microinsertions are a cause of human inherited disease but have also occurred during vertebrate evolution. For both microinsertions and the insertion of transposable elements, mechanistic models that have explanatory value in the context of genetic disease are also useful to account for the nature and location of evolutionary insertions.

Keywords: gross insertions; microinsertions; microinsertion polymorphisms; indels; transposable elements; evolution


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Web Links

Chorionic gonadotropin, beta polypeptide (CGB); Locus ID: 1082. LocusLink:

Luteinizing hormone beta polypeptide (LHB); Locus ID: 3972. LocusLink:

Transaldolase 1 (TALDO1); Locus ID: 6888. LocusLink:

Chorionic gonadotropin, beta polypeptide (CGB); MIM number: 118860. OMIM:‐post/Omim/dispmim?118860

Luteinizing hormone beta polypeptide (LHB); MIM number: 152780. OMIM:‐post/Omim/dispmim?152780

Transaldolase 1 (TALDO1); MIM number: 602063. OMIM:‐post/Omim/dispmim?602063

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Cooper, David N(Jul 2006) Gross Insertions and Microinsertions in Evolution. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005095]