Gross Insertions and Microinsertions in Evolution

David N Cooper, University of Wales College of Medicine, Cardiff, UK

Published online: July 2006

DOI: 10.1038/npg.els.0005095

Gross insertions and microinsertions are a cause of human inherited disease but have also occurred during vertebrate evolution. For both microinsertions and the insertion of transposable elements, mechanistic models that have explanatory value in the context of genetic disease are also useful to account for the nature and location of evolutionary insertions.

Keywords: gross insertions; microinsertions; microinsertion polymorphisms; indels; transposable elements; evolution

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    book Cooper DN (1999) Human Gene Evolution. Oxford, UK: BIOS Scientific Publishers.
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 Web Links
    ePath Chorionic gonadotropin, beta polypeptide (CGB); Locus ID: 1082. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1082
    ePath Luteinizing hormone beta polypeptide (LHB); Locus ID: 3972. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3972
    ePath Transaldolase 1 (TALDO1); Locus ID: 6888. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6888
    ePath Chorionic gonadotropin, beta polypeptide (CGB); MIM number: 118860. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?118860
    ePath Luteinizing hormone beta polypeptide (LHB); MIM number: 152780. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?152780
    ePath Transaldolase 1 (TALDO1); MIM number: 602063. OMIM: http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?602063

Related Sub-Topics:

Evolutionary Genomics | Molecular Evolution | Evolutionary Processes | Evolution of Coding and Functional Modules
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Article Title: Gross Insertions and Microinsertions in Evolution
 
How to Cite close
Cooper, David N(Jul 2006) Gross Insertions and Microinsertions in Evolution. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005095]