The selectionist view of molecular evolution maintains that a large fraction of molecular variation seen in natural populations is due to beneficial mutations.
Keywords: molecular; variation; selection
Evolution: Selectionist View
Andreas Wagner, University of New Mexico, New Mexico, USA
Published online: December 2007
DOI: 10.1002/9780470015902.a0005105.pub2
| Further Reading | |
| Bernardi G (2007) The neoselectionist theory of genome evolution. Proceedings of the National Academy of Science of the USA 104(20): 8385–8390. | |
| Bustamante CD, Fledel-Alon A, Williamson S et al. (2005) Natural selection on protein-coding genes in the human genome. Nature 437: 1153–1157. | |
| Ewens WJ (1977) Population genetics theory in relation to the neutralist-selectionist controversy. Advances in Human Genetics 8: 67–134. | |
| book Gillespie J (1991) The Causes of Molecular Evolution. New York: Oxford University Press. | |
| Harris EE and Meyer D (2006) The molecular signature of selection underlying human adaptations. American Journal of Physical Anthropology 43(suppl.): 89–130. | |
| book Kimura M (1983) The Neutral Theory of Molecular Evolution. Cambridge, UK: Cambridge University Press. | |
| Kreitman M and Akashi H (1995) Molecular evidence for natural selection. Annual Review of Ecology and Systematics 26: 403–422. | |
| McVean G and Spencer CC (2006) Scanning the human genome for signals of selection. Current Opinion in Genetics & Development 16: 624–629. | |
| Ponting CP and Lunter G (2006) Signatures of adaptive evolution within human non-coding sequence. Human Molecular Genetics 15: R170–R175. | |
| Ronald J and Akey JM (2005) Genome-wide scans for loci under selection in humans. Human Genomics 2: 113–125. | |
| Sunyaev S, Kondrashov FA, Bork P and Ramensky V (2003) Impact of selection, mutation rate and genetic drift on human genetic variation. Human Molecular Genetics 12: 3325–3330. | |
