Evolutionary Distance


Evolutionary distance refers to the cumulative evolutionary change between two DNA or protein sequences that were derived from a common ancestral sequence.

Keywords: distance measures; substitution models; distance estimation; nucleotide substitution; amino acid substitution

Figure 1.

(a) One‐parameter model of nucleotide substitution. In this model, the rate of substitution in each direction is α substitutions per site per unit time. (b) Two‐parameter model of nucleotide substitution. In this model, the rate of transition (α) may not be equal to the rate of each of the two types of transversion (β).



Jukes TH and Cantor CR (1969) Evolution of protein molecules. In: Munro HN (ed.) Mammalian Protein Metabolism, pp. 21–123. New York: Academic Press

Kimura (1980) The Neutral Theory of Molecular Evolution. New York: Cambridge University Press.

Li WH (1997) Molecular Evolution. Sunderland, MA: Sinauer Associates.

Nei M and Kumar S (2000) Molecular Evolution and Phylogenetics. New York: Oxford University Press.

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Li, Wen‐Hsiung(Jul 2006) Evolutionary Distance. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005107]