Nucleotide Substitution: Rate of


The rate of nucleotide substitution in a DNA sequence is defined as the number of nucleotide substitutions per site per unit time. It is a basic quantity in the study of DNA sequence evolution.

Keywords: nucleotide substitution; rate of evolution

Figure 1.

Divergence of two sequences. Sequences 1 and 2 were derived from a common ancestral sequence t years ago.



Li WH (1997) Molecular Evolution. Sunderland, MA: Sinauer Associates.

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Li, Wen‐Hsiung(Jul 2006) Nucleotide Substitution: Rate of. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005109]