Pseudogenes: Age


Pseudogenes present valuable evolutionary markers since they undergo neutral evolution. Determination of the age of pseudogenes over relatively short distances of time can confirm the order of evolutionary emergence and provide evidence for common ancestry.

Keywords: pseudogene; processed pseudogene; retroprocessed pseudogene; age

Figure 1.

The phylogenetic tree and evolutionary relationships for a mouse pseudogene. The substitution rates for the functional gene and the retroprocessed pseudogene from the time since inactivation (Ti) are equal to ai and bi, respectively.



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Further Reading

Bensasson D, Zhang D‐X, Hartl DL and Hewitt GM (2001) Mitochondrial pseudogenes: evolution's misplaced witnesses. Trends in Ecology and Evolution 16: 314–321.

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Zheng D and Gerstein MB (2007) The ambiguous boundary between genes and pseudogenes: the dead rise up, or do they? Trends in Genetics 23: 219–224.

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How to Cite close
Rhoads, Allen R, and Friedberg, Felix(Apr 2008) Pseudogenes: Age. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0005119.pub2]