Pseudogenes: Age

Abstract

Pseudogenes present valuable evolutionary markers since they undergo neutral evolution. Determination of the age of pseudogenes over relatively short distances of time can confirm the order of evolutionary emergence and provide evidence for common ancestry.

Keywords: pseudogene; processed pseudogene; retroprocessed pseudogene; age

Figure 1.

The phylogenetic tree and evolutionary relationships for a mouse pseudogene. The substitution rates for the functional gene and the retroprocessed pseudogene from the time since inactivation (Ti) are equal to ai and bi, respectively.

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References

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Further Reading

Bensasson D, Zhang D‐X, Hartl DL and Hewitt GM (2001) Mitochondrial pseudogenes: evolution's misplaced witnesses. Trends in Ecology and Evolution 16: 314–321.

D'Errico I, Gadaleta G and Saccone C (2004) Pseudogenes in metazoa: origin and features. Briefings in Functional Genomics and Proteomics 3: 157–167.

Goncalves I, Duret L and Mouchiroud D (2000) Nature and structure of human genes that generate retropseudogenes. Genome Research 10: 672–678.

Graur D and Li W‐H (2000) Fundamentals of Molecular Evolution. Sunderland, MA: Sinauer Associates.

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How to Cite close
Rhoads, Allen R, and Friedberg, Felix(Apr 2008) Pseudogenes: Age. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005119.pub2]