Pseudogenes: Patterns of Mutation


Pseudogenes lack biological function and are therefore free from selective pressure. This makes them extremely useful tools for the study of mutation processes and especially to estimate the pattern of spontaneous mutation in the genome. The nonrandomness of the mutational processes and the existence of mutational hot spots have also been deduced from studies on pseudogenes.

Keywords: pseudogene; mutation pattern; spontaneous mutation


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Further Reading

Li WH (1997) Molecular Evolution. Sunderland, MA: Sinauer Associates.

Web Links

Glucosidase, beta; acid (includes glucosylceramidase) (GBA); Locus ID: 2629. LocusLink:

Phosphomannomutase 2 (PMM2); LocusID: 5373. LocusLink:

Glucosidase, beta; acid (includes glucosylceramidase) (GBA); MIM number: 606463. OMIM:‐post/Omim/dispmim?606463

Phosphomannomutase 2 (PMM2); MIM number: 601785. OMIM:‐post/Omim/dispmim?601785

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Martínez‐Arias, Rosa, Calafell, Francesc, and Bertranpetit, Jaume(Jul 2006) Pseudogenes: Patterns of Mutation. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005120]