Anxiety Disorders


Anxiety disorders are psychiatric syndromes in which pathological anxiety is the dominant feature. The results of family studies and twin studies suggest a genetic contribution to these disorders, especially in the case of panic disorder. The molecular search for responsible genes has just begun.

Keywords: anxiety; neurotransmitters; panic disorder; obsessive–compulsive disorder; twin studies


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Further Reading

Carey G and Gottesman I (1981) Twin and family studies of anxiety, phobic and obsessive disorders. In: Klein D and Rabkin J (eds.) Anxiety: New Research and Changing Concepts. New York, NY: Raven Press.

Fyer A (2000) Anxiety disorders: genetics. In: Sadock B and Sadock V (eds.) Comprehensive Textbook of Psychiatry, 7th edn. Philadelphia, PA: Lippincott, Williams and Wilkins.

Web Links

corticotropin releasing hormone receptor 2 (CRHR2); Locus ID: 1395. LocusLink:

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (SLC6A3); Locus ID: 6531. LocusLink:

monoamine oxidase A (MAOA); Locus ID: 4128. LocusLink:

catechol‐O‐methyltransferase (COMT); Locus ID: 1312. LocusLink:

corticotropin releasing hormone receptor 2 (CRHR2); MIM number: 602034. OMIM:‐post/Omim/dispmim?602034

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (SLC6A3); MIM number: 126455. OMIM:‐post/Omim/dispmim?126455

monoamine oxidase A (MAOA); MIM number: 309850. OMIM:‐post/Omim/dispmim?309850

catechol‐O‐methyltransferase (COMT); MIM number: 116790. OMIM:‐post/Omim/dispmim?116790

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Benjamin, Jonathan, and Kennedy, James(Jul 2006) Anxiety Disorders. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005153]