Autism: Genetics

Abstract

Autistic disorder is a highly heritable complex genetic disorder. First‐degree relatives are at increased risk for a broader phenotype of less severe impairments in social and communication development, as well as restricted and repetitive behaviors.

Keywords: autism; complex genetics; multiplicative inheritance; pervasive developmental disorders

Further Reading

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Web Links

Gamma‐aminobutyric acid (GABA) A receptor, beta 3 (GABRB3); Locus ID: 2562. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2562

Reelin (RELN); Locus ID: 5649. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=5649

Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4); Locus ID: 6532. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=6532

Ubiquitin protein ligase E3A (human papilloma virus E6‐associated protein, Angelman syndrome) (UBE3A); Locus ID: 7337. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7337

Wingless‐type MMTV integration site family member 2 (WNT2); Locus ID: 7472. LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=7472

Gamma‐aminobutyric acid (GABA) A receptor, beta 3 (GABRB3); MIM number: 137192. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?137192

Reelin (RELN); MIM number: 600514. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?600514

Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4); MIM number: 182138. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?182138

Ubiquitin protein ligase E3A (human papilloma virus E6‐associated protein, Angelman syndrome) (UBE3A); MIM number: 601623. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?601623

Wingless‐type MMTV integration site family member 2 (WNT2); MIM number: 147870. OMIM: http://www.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?147870

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How to Cite close
Cook Jr, Edwin H(Jul 2006) Autism: Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005159]