Schizophrenia: Molecular Genetics

Abstract

Molecular genetic studies of schizophrenia have used both linkage and association approaches. Both types of study have resulted in conflicting findings, and unequivocal evidence for linkage or association is as yet lacking. However, systematic linkage studies have revealed several chromosomal areas of potential interest, and candidate gene association studies have suggested that variation within the HTR2A and DRD3 genes might confer susceptibility.

Keywords: schizophrenia; linkage; association; HTR2A; DRD3

References

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Further Reading

Baron M (2001) Genetics of schizophrenia and the new millennium: progress and pitfalls. American Journal of Human Genetics 68: 299–312.

Gottesman II (1991) Schizophrenia Genesis: The Origins of Madness.. New York, NY: WH Freeman.

McGuffin P, Owen MJ and Farmer AE (1995) Genetic basis of schizophrenia. Lancet 346: 678–682.

O'Donovan MC and Owen MJ (1999) Candidate gene association studies of schizophrenia. American Journal of Human Genetics 65: 587–592.

Owen MJ, Cardno AG and O'Donovan MC (2000) Psychiatric genetics: back to the future. Molecular Psychiatry 5: 22–31.

Owen MJ and O'Donovan MC (2002) Schizophrenia. In: Plomin R, De Fries JC, Craig IC and McGuffin P (eds.) Behavioral Genetics in a Postgenomics World. Washington DC: APA Books.

Sherrington R, Rogaev EI, Liang Y, et al. (1995) Cloning of a gene bearing missense mutations in early‐onset familial Alzheimer's disease. Nature 375: 754–760.

Web Links

5‐hydroxytryptamine (serotonin) receptor 2A (HTR2A); MIM number: 182135. OMIM: http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?182135

Dopamine receptor D3 (DRD3); MIM number: 126451; OMIM: http://www3.ncbi.nlm.nih.gov/htbin‐post/Omim/dispmim?126451

5‐hydroxytryptamine (serotonin) receptor 2A (HTR2A); Locus ID: 3356; LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3356

Dopamine receptor D3 (DRD3); Locus ID: 1814; LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=1814

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How to Cite close
Owen, Michael J(Jul 2006) Schizophrenia: Molecular Genetics. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005160]