Nick Craddock, University of Wales College of Medicine, Cardiff, UK
Ian Jones, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
Lindsey Kent, Queen Elizabeth Psychiatric Hospital, Birmingham, UK
Published online: July 2006
DOI: 10.1038/npg.els.0005161
Mood disorders are common complex genetic disorders in which the core feature is a pathological disturbance of mood ranging from extreme elation (mania) to severe depression. Large-scale positional and candidate gene studies are ongoing and promising findings are emerging but robust confirmation is awaited.
Keywords: bipolar disorder; unipolar disorder; major depression; affective disorders; psychosis
| References | |
| book APA (1994) "Diagnostic and Statistical Manual for Mental Disorders", 4th edn. Washington, DC: American Psychiatric Association. | |
| Baron M, Risch N, Hamburger R, et al. (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326: 289–292. | |
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| Further Reading | |
| book Barondes SH (1998) Mood Genes. Hunting for Origins of Mania and Depression. Harmondsworth, UK: Penguin. | |
| book Charney DS, Nestler EJ and Bunney BS (eds.) (1999) "Neurobiology of Mental Illness" Oxford, UK: Oxford University Press. | |
| Craddock N and Jones I (1999) Genetics of bipolar disorder. Journal of Medical Genetics 36: 585–594. | |
| Farmer AE, Williams J and Jones I (1994) Phenotypic definitions of psychotic illness for molecular genetic research. American Journal of Medical Genetics (Neuropsychiatric Genetics) 54: 365–371. | |
| book Goodwin FK and Jamison KR (1990) Manic-Depressive Illness. Oxford, UK: Oxford University Press. | |
| Malhi GS, Moore J and McGuffin P (2000) The genetics of major depressive disorder. Current Psychiatry Reports 2: 165–169. | |
| book McGuffin P, Owen MJ, O'Donovan MC, Thapar A and Gottesman II (1994). Seminar in Psychiatric Genetics. London, UK: Gaskell. | |
| book Paykel ES (ed.) (1992) Handbook of Affective Disorders,. 2nd edn. Edinburgh, UK: Churchill Livingstone. | |
| book Soares JC and Gershon S (eds.) (2000) Bipolar Disorders. Basic Mechanisms and Therapeutic Implications. New York, NY: Marcel Decker. | |
| Sullivan PS, Neale MC and Kendler KS (2000) Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry 157: 1552–1562. | |
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