Mood Disorders: Molecular

Abstract

Mood disorders are common complex genetic disorders in which the core feature is a pathological disturbance of mood ranging from extreme elation (mania) to severe depression. Large‐scale positional and candidate gene studies are ongoing and promising findings are emerging but robust confirmation is awaited.

Keywords: bipolar disorder; unipolar disorder; major depression; affective disorders; psychosis

References

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Further Reading

Barondes SH (1998) Mood Genes. Hunting for Origins of Mania and Depression. Harmondsworth, UK: Penguin.

Charney DS, Nestler EJ and Bunney BS (eds.) (1999) Neurobiology of Mental Illness Oxford, UK: Oxford University Press.

Craddock N and Jones I (1999) Genetics of bipolar disorder. Journal of Medical Genetics 36: 585–594.

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Paykel ES (ed.) (1992) Handbook of Affective Disorders,. 2nd edn. Edinburgh, UK: Churchill Livingstone.

Soares JC and Gershon S (eds.) (2000) Bipolar Disorders. Basic Mechanisms and Therapeutic Implications. New York, NY: Marcel Decker.

Sullivan PS, Neale MC and Kendler KS (2000) Genetic epidemiology of major depression: review and meta‐analysis. American Journal of Psychiatry 157: 1552–1562.

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How to Cite close
Craddock, Nick, Jones, Ian, and Kent, Lindsey(Jul 2006) Mood Disorders: Molecular. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005161]