Kinases and Phosphatases and Human Disorders: The First Drugs


Kinases are enzymes that transfer phosphate groups from simple precursors (adenosine‐ or guanosine‐triphosphate) to proteins, lipids or carbohydrates. Phosphatases catalyse the reverse reaction and produce free phosphate.

Keywords: phosphatase; kinase; cancer; PTP; human disorders; drugs


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Further Reading

Andersen JN, Jansen PG, Echwald SM et al. (2004) A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. The FASEB Journal 18: 8–30.

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Hooft van Huijsduijnen R, Sauer W, Bombrun A and Swinnen D (2004) Prospects for inhibitors of PTP1B (Protein Tyrosine Phosphatase 1B) as anti‐diabetic drugs. Journal of Medical Chemistry 47: 4142–4146.

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Stoker AW (2005) Protein tyrosine phosphatases and signalling. The Journal of Endocrinology 185: 19–33.

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van Huijsduijnen, Rob Hooft(Jan 2007) Kinases and Phosphatases and Human Disorders: The First Drugs. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1002/9780470015902.a0005167.pub2]