Rob Hooft van Huijsduijnen, Serono Pharmaceutical Research Institute, Geneva, Switzerland
Published online: January 2007
DOI: 10.1002/9780470015902.a0005167.pub2
Kinases are enzymes that transfer phosphate groups from simple precursors (adenosine- or guanosine-triphosphate) to proteins, lipids or carbohydrates. Phosphatases catalyse the reverse reaction and produce free phosphate.
Keywords: phosphatase; kinase; cancer; PTP; human disorders; drugs
| References | |
| Duerr EM, Rollbrocker B, Hayashi Y et al. (1998) PTEN mutations in gliomas and glioneuronal tumors. Oncogene 16: 2259–2264. | |
| Elchebly M, Payette P, Michaliszyn E et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283: 1544–1548. | |
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| Further Reading | |
| Andersen JN, Jansen PG, Echwald SM et al. (2004) A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. The FASEB Journal 18: 8–30. | |
| Dixon JE (1996) Protein tyrosine phosphatases: their roles in signal transduction. Recent Progress in Hormone Research 51: 405–414; discussion 415. | |
| book Goldstein JB (1998) Tyrosine Phosphoprotein Phosphatases (Protein Profile). Oxford: Oxford University Press. | |
| book Hardie GH and Hanks S (1995) The Protein Kinase FactsBook. Protein-Serine Kinases. London: Academic Press. | |
| book Hardie GH and Hanks S (1995) The Protein Kinase FactsBook. Protein-Tyrosine Kinases. London: Academic Press. | |
| book Hesketh R (1995) The Oncogene FactsBook. London: Academic Press. | |
| Hooft van Huijsduijnen R (1998) Protein tyrosine phosphatases: counting the trees in the forest. Gene 225(1–2): 1–8. | |
| Hooft van Huijsduijnen R, Sauer W, Bombrun A and Swinnen D (2004) Prospects for inhibitors of PTP1B (Protein Tyrosine Phosphatase 1B) as anti-diabetic drugs. Journal of Medical Chemistry 47: 4142–4146. | |
| Hunter T (1987) A thousand and one protein kinases. Cell 50(6): 823–829. | |
| Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80(2): 225–236. | |
| Stoker AW (2005) Protein tyrosine phosphatases and signalling. The Journal of Endocrinology 185: 19–33. | |
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