Kinases and Phosphatases and Human Disorders: The First Drugs

Abstract

Kinases are enzymes that transfer phosphate groups from simple precursors (adenosine‐ or guanosine‐triphosphate) to proteins, lipids or carbohydrates. Phosphatases catalyse the reverse reaction and produce free phosphate.

Keywords: phosphatase; kinase; cancer; PTP; human disorders; drugs

References

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Further Reading

Andersen JN, Jansen PG, Echwald SM et al. (2004) A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. The FASEB Journal 18: 8–30.

Dixon JE (1996) Protein tyrosine phosphatases: their roles in signal transduction. Recent Progress in Hormone Research 51: 405–414; discussion 415.

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Hardie GH and Hanks S (1995) The Protein Kinase FactsBook. Protein‐Tyrosine Kinases. London: Academic Press.

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Hooft van Huijsduijnen R (1998) Protein tyrosine phosphatases: counting the trees in the forest. Gene 225(1–2): 1–8.

Hooft van Huijsduijnen R, Sauer W, Bombrun A and Swinnen D (2004) Prospects for inhibitors of PTP1B (Protein Tyrosine Phosphatase 1B) as anti‐diabetic drugs. Journal of Medical Chemistry 47: 4142–4146.

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Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80(2): 225–236.

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van Huijsduijnen, Rob Hooft(Jan 2007) Kinases and Phosphatases and Human Disorders: The First Drugs. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005167.pub2]