DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis


The application of DNA analysis to unravel an individual's parentage is now over 15 years old. The techniques have evolved and the applications expanded as the interest in defining relationships continues to grow.

Keywords: Jeffreys; paternity; relationship analysis; short tandem repeat profiling


Jeffreys AJ, Brookfield JFY and Semeonoff RS (1985a) Positive identification of an immigration test‐case using human DNA fingerprints. Nature 317: 818–819.

Jeffreys AJ, Turner M and Debenham P (1991) The efficiency of multilocus DNA fingerprint probes for individualization and establishment of family relationships, determined from extensive casework. American Journal of Human Genetics 48: 824–840.

Jeffreys AJ, Wilson V and Thein SL (1985b) Individual‐specific fingerprints of human DNA. Nature 316: 76–79.

Mullis KB (1990) The unusual origin of the polymerase chain reaction. Scientific American 262: 36–43.

Peters C, Schneider V, Epplen JT and Poche H (1991) Individual‐specific DNA fingerprints in man using the oligonucleotide probe (GTG)5/(CAC)5. European Journal of Clinical Chemistry and Clinical Biochemistry 29: 321–325.

Smith JC, Newton CR, Alves A, et al. (1990) Highly polymorphic minisatellite DNA probes. Further evaluation for individual identification and paternity testing. Journal of the Forensic Science Society 30: 3–18.

Thomson JA, Ayres KL, Pilotti V, et al. (2001) Analysis of disputed single‐parent/child and sibling relationships using 16 STR loci. International Journal of Legal Medicine 115: 128–134.

Thomson JA, Pilotti V, Stevens P, Ayres KL and Debenham PG (1999) Validation of short tandem repeat analysis for the investigation of cases of disputed paternity. Forensic Science International 100: 1–16.

UK Department of Health (2001) Code of Practice and Guidance on Paternity Testing Services. London, UK: United Kingdom Department of Health.

Vassart G, Georges M, Monsieur R, et al. (1987) A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA. Science 235: 683–684.

Wong Z, Wilson V, Patel I, Povey S and Jeffreys AJ (1987) Characterization of a panel of highly variable minisatellites cloned from human DNA. Annals of Human Genetics 51: 269–288.

Further Reading

Debenham PG (2002) Minisatellite and microsatellite DNA fingerprinting. In: Day INM (ed.) Principles and Practice. Molecular Genetic Epidemiology – A Laboratory Perspective, pp. 87–106. Berlin, NY: Springer‐Verlag.

Debenham P and Martin PD (2000) DNA in forensic science. In: Walker JM and Rapley R (eds.) Molecular Biology and Biotechnology, 4th edn, pp. 295–315. London, UK: The Royal Society of Chemistry.

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How to Cite close
Debenham, Paul G(Jul 2006) DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005202]