DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis

Paul G Debenham, University Diagnostics Ltd, Teddington, UK

Published online: July 2006

DOI: 10.1038/npg.els.0005202

The application of DNA analysis to unravel an individual's parentage is now over 15 years old. The techniques have evolved and the applications expanded as the interest in defining relationships continues to grow.

Keywords: Jeffreys; paternity; relationship analysis; short tandem repeat profiling

 References
    Jeffreys AJ, Brookfield JFY and Semeonoff RS (1985a) Positive identification of an immigration test-case using human DNA fingerprints. Nature 317: 818–819.
    Jeffreys AJ, Turner M and Debenham P (1991) The efficiency of multilocus DNA fingerprint probes for individualization and establishment of family relationships, determined from extensive casework. American Journal of Human Genetics 48: 824–840.
    Jeffreys AJ, Wilson V and Thein SL (1985b) Individual-specific fingerprints of human DNA. Nature 316: 76–79.
    Mullis KB (1990) The unusual origin of the polymerase chain reaction. Scientific American 262: 36–43.
    Peters C, Schneider V, Epplen JT and Poche H (1991) Individual-specific DNA fingerprints in man using the oligonucleotide probe (GTG)5/(CAC)5. European Journal of Clinical Chemistry and Clinical Biochemistry 29: 321–325.
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    Thomson JA, Ayres KL, Pilotti V, et al. (2001) Analysis of disputed single-parent/child and sibling relationships using 16 STR loci. International Journal of Legal Medicine 115: 128–134.
    Thomson JA, Pilotti V, Stevens P, Ayres KL and Debenham PG (1999) Validation of short tandem repeat analysis for the investigation of cases of disputed paternity. Forensic Science International 100: 1–16.
    book UK Department of Health (2001) Code of Practice and Guidance on Paternity Testing Services. London, UK: United Kingdom Department of Health.
    Vassart G, Georges M, Monsieur R, et al. (1987) A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA. Science 235: 683–684.
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 Further Reading
    book Debenham PG (2002) "Minisatellite and microsatellite DNA fingerprinting". In: Day INM (ed.) Principles and Practice. Molecular Genetic Epidemiology – A Laboratory Perspective, pp. 87–106. Berlin, NY: Springer-Verlag.
    book Debenham P and Martin PD (2000) "DNA in forensic science". In: Walker JM and Rapley R (eds.) Molecular Biology and Biotechnology, 4th edn, pp. 295–315. London, UK: The Royal Society of Chemistry.

Related Sub-Topics:

Techniques and Tools in Clinical Genetics | Forensic Genetics | Science and Society - General | Bioethics
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Article Title: DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis
 
How to Cite close
Debenham, Paul G(Jul 2006) DNA Fingerprinting, Paternity Testing and Relationship (Immigration) Analysis. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1038/npg.els.0005202]