Genetic Isolates and Behavioral Gene Searches


Genetically isolated populations, created via physical isolation, founder effect and ethnic inbreeding, help to create relatively more homogeneous study populations. In the study of disorders of multifactorial and multiple gene effects, use of such populations should allow for enhanced identification of susceptibility genes by limiting genetic heterogeneity.

Keywords: genetic isolates; founder effect; homozygosity; inbreeding; surname analysis


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Further Reading

Faraone ST, Tsuang MG and Tsuang DW (1999) Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York, NY: Guilford Publications.

Haines JL and Pericak‐Vance MA (1998) Approaches to Gene Mapping in Complex Human Diseases. New York, NY: Wiley‐Liss.

Peltonen L, Jalanko A and Varilo T (1999) Molecular genetics of the Finnish disease heritage. Human Molecular Genetics 8: 1913–1923.

Sham P (1998) Statistics in Human Genetics. London, UK: Arnold.

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Pato, Carlos N, Schindler, Kim M, and Pato, Michele T(Jul 2006) Genetic Isolates and Behavioral Gene Searches. In: eLS. John Wiley & Sons Ltd, Chichester. [doi: 10.1038/npg.els.0005227]