Carlos N Pato, State University of New York, Syracuse, New York, USA
Kim M Schindler, State University of New York at Buffalo, Buffalo, New York, USA
Michele T Pato, State University of New York, Syracuse, New York, USA
Published online: July 2006
DOI: 10.1038/npg.els.0005227
Genetically isolated populations, created via physical isolation, founder effect and ethnic inbreeding, help to create relatively more homogeneous study populations. In the study of disorders of multifactorial and multiple gene effects, use of such populations should allow for enhanced identification of susceptibility genes by limiting genetic heterogeneity.
Keywords: genetic isolates; founder effect; homozygosity; inbreeding; surname analysis
| References | |
| Gulcher J and Stefansson K (1998) Population genomics: laying the groundwork for genetic disease modeling and targeting. Clinical Chemistry and Laboratory Medicine 36: 523–527. | |
| Hader WJ, Seland TP, Hader MB, Harris CJ and Dietrich DW (1996) The occurrence of multiple sclerosis in the Hutterites of North America. Canadian Journal of Neurological Sciences 23: 291–295. | |
| Kittles RA, Bergen AW, Urbanek M, et al. (1999) Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck. American Journal of Physical Anthropology 108: 381–399. | |
| Morgan K, Holmes TM, Schlaut J, et al. (1980) Genetic variability of HLA in the Dariusleut Hutterites. A comparative genetic analysis of the Hutterites, the Amish, and other selected Caucasian populations. American Journal of Human Genetics 32: 246–257. | |
| Myles-Worsley M, Coon H, Tiobech J, et al. (1999) Genetic epidemiological study of schizophrenia in Palau, Micronesia: prevalence and familiality. American Journal of Medical Genetics 88: 4–10. | |
| Pato CN, Azevedo MH, Pato MT, et al. (1997) Selection of homogenous population for genetic study: the Portugal genetics of psychosis project. American Journal of Medical Genetics 74: 286–288. | |
| Peltonen L (1997) Molecular background of the Finnish disease heritage. Annals of Medicine 29: 553–556. | |
| Peltonen L (2000) Positional cloning of disease genes: advantages of genetic isolates. Human Heredity 50: 66–75. | |
| Schindler K, Dalla Torre C, Bauer A, et al. (1999) Identification of a highly homogeneous population for genetic study of psychiatric disorders. CNS Spectrums 4(5): 22–24. | |
| Sheffield VC, Stone EM and Carmi R (1998) Use of isolated inbred human populations for identification of disease genes. Trends in Genetics 14: 391–396. | |
| Williams JT (1993) Origin and population structure of the Icelanders. Human Biology 65: 167–191. | |
| Further Reading | |
| book Faraone ST, Tsuang MG and Tsuang DW (1999) Genetics of Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York, NY: Guilford Publications. | |
| book Haines JL and Pericak-Vance MA (1998) Approaches to Gene Mapping in Complex Human Diseases. New York, NY: Wiley-Liss. | |
| Peltonen L, Jalanko A and Varilo T (1999) Molecular genetics of the Finnish disease heritage. Human Molecular Genetics 8: 1913–1923. | |
| book Sham P (1998) Statistics in Human Genetics. London, UK: Arnold. | |
Copyright © 2000-2013 by John Wiley & Sons, Inc., or related companies. All rights reserved.
